Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu, Jin Ding Huang, Shi Wei Huang, Tzyh Chyuan Hour, Yung Kai Huang, Yu Mei Hsueh, Hung Yi Chiou, Te Chang Lee, Kun Yan Jan, Chien Jen Chen, Yeong Shiau Pu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalJournal of Biomedical Science
Volume15
Issue number2
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Androgen Receptors
Polymorphism
Genes
Carcinoma
DNA Sequence Analysis
Tobacco Products
Habits
Leukocytes
Smoking
Interviews
DNA

Keywords

  • Bladder neoplasms
  • Carcinogenesis
  • Tobacco
  • Trinucleotide repeats
  • Urinary tract

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Liu, C. H., Huang, J. D., Huang, S. W., Hour, T. C., Huang, Y. K., Hsueh, Y. M., ... Pu, Y. S. (2008). Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. Journal of Biomedical Science, 15(2), 261-269. https://doi.org/10.1007/s11373-007-9215-x

Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. / Liu, Chin Hung; Huang, Jin Ding; Huang, Shi Wei; Hour, Tzyh Chyuan; Huang, Yung Kai; Hsueh, Yu Mei; Chiou, Hung Yi; Lee, Te Chang; Jan, Kun Yan; Chen, Chien Jen; Pu, Yeong Shiau.

In: Journal of Biomedical Science, Vol. 15, No. 2, 03.2008, p. 261-269.

Research output: Contribution to journalArticle

Liu, CH, Huang, JD, Huang, SW, Hour, TC, Huang, YK, Hsueh, YM, Chiou, HY, Lee, TC, Jan, KY, Chen, CJ & Pu, YS 2008, 'Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma', Journal of Biomedical Science, vol. 15, no. 2, pp. 261-269. https://doi.org/10.1007/s11373-007-9215-x
Liu, Chin Hung ; Huang, Jin Ding ; Huang, Shi Wei ; Hour, Tzyh Chyuan ; Huang, Yung Kai ; Hsueh, Yu Mei ; Chiou, Hung Yi ; Lee, Te Chang ; Jan, Kun Yan ; Chen, Chien Jen ; Pu, Yeong Shiau. / Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma. In: Journal of Biomedical Science. 2008 ; Vol. 15, No. 2. pp. 261-269.
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