Androgen receptor gene polymorphism may affect the risk of urothelial carcinoma

Chin Hung Liu, Jin Ding Huang, Shi Wei Huang, Tzyh Chyuan Hour, Yung Kai Huang, Yu Mei Hsueh, Hung Yi Chiou, Te Chang Lee, Kun Yan Jan, Chien Jen Chen, Yeong Shiau Pu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The study sought to explore if androgen receptor gene (AR) polymorphisms are associated with the risk of urothelial carcinoma (UC) which is male-predominant. AR CAG and GGN repeat lengths were analyzed in 277 UC cases and 280 age and sex-matched controls by direct sequencing of leukocyte DNA. Smoking habits were obtained using a structured questionnaire interview. Relative risks were compared between groups categorized by all possible cutoffs of AR CAG and GGN repeat lengths. Men and women who had 23 and 44 (cumulative) CAG repeats had a significantly greater risk of UC, respectively (OR 2.09, 95% CI: 1.05-4.17, p = 0.036 and OR 4.95, 95% CI: 1.56-15.73, p = 0.007). Amongst males who were medium-dose cigarette smokers, those who had 23 CAG and shorter GGN (

Original languageEnglish
Pages (from-to)261-269
Number of pages9
JournalJournal of Biomedical Science
Volume15
Issue number2
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Bladder neoplasms
  • Carcinogenesis
  • Tobacco
  • Trinucleotide repeats
  • Urinary tract

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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