Androgen modulates cardiac fibrosis contributing to gender differences on heart failure

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chronic heart failure (HF) is a major health problem throughout the world. Gender has significant effects on the pathophysiology of HF. Low levels of free testosterone are independently associated with increased chronic HF symptoms and mortality. Cardiac fibrosis plays a pivotal role in structural remodeling in HF. Transforming growth factor (TGF)-β, angiotensin II and oxidative stress contribute to the activity/extent of cardiac fibrosis. Androgen deficiency can up-regulate TGF-β expression under angiotensin II stimulation in vivo. In this review, we summarized the potential mechanisms accounting for the effects of androgen on cardiac fibrosis through regulating fibrocytes activity under TGF, which can explain wound healing and cardiac fibrosis in male with acute myocardial injury and chronic HF.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalAging Male
Volume16
Issue number1
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Androgen
  • Fibroblasts
  • Fibrosis
  • Heart failure
  • Testosterone
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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