Abstract
Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma with a relatively favorable prognosis. However, a certain group of ALCLs is highly aggressive, featuring paraneoplastic leukocytosis (PL) in clinical presentation. The present study evaluated five cases of ALCL presenting with PL, including four men and one woman, with a median age of 58years. All cases revealed leukocytosis with a range from 15.3 to 112.9×10 3/μL. Five (100%) and 4 (80%) cases demonstrated immunoreactivity for granulocyte-colony-stimulating factor (G-CSF) and tumor necrosis factor-alpha (TNF-α), respectively. There were significant differences in the expression of G-CSF and TNF-α between ALCL cases with or without PL (p<0.05 for both). The prognosis of ALCL patients with PL was poor. Four of five patients (80%) died of the disease within a median survival time of 3.5weeks. The release of G-CSF and TNF-α from lymphoma cells may associate with ALCL presenting with PL, leading to cytokine crisis and even poorer prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 794-801 |
| Number of pages | 8 |
| Journal | APMIS |
| Volume | 119 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2011 |
| Externally published | Yes |
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Keywords
- ALK
- Anaplastic large cell lymphoma
- G-CSF
- Paraneoplastic leukocytosis
- TNF-α
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Immunology and Allergy
- Microbiology (medical)
Cite this
Anaplastic large cell lymphoma with paraneoplastic leukocytosis : A clinicopathological analysis of five cases. / Chang, I. Wei; Chen, Han Ku; Ma, Ming Chun; Huang, Wan Ting.
In: APMIS, Vol. 119, No. 11, 01.11.2011, p. 794-801.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anaplastic large cell lymphoma with paraneoplastic leukocytosis
T2 - A clinicopathological analysis of five cases
AU - Chang, I. Wei
AU - Chen, Han Ku
AU - Ma, Ming Chun
AU - Huang, Wan Ting
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma with a relatively favorable prognosis. However, a certain group of ALCLs is highly aggressive, featuring paraneoplastic leukocytosis (PL) in clinical presentation. The present study evaluated five cases of ALCL presenting with PL, including four men and one woman, with a median age of 58years. All cases revealed leukocytosis with a range from 15.3 to 112.9×10 3/μL. Five (100%) and 4 (80%) cases demonstrated immunoreactivity for granulocyte-colony-stimulating factor (G-CSF) and tumor necrosis factor-alpha (TNF-α), respectively. There were significant differences in the expression of G-CSF and TNF-α between ALCL cases with or without PL (p<0.05 for both). The prognosis of ALCL patients with PL was poor. Four of five patients (80%) died of the disease within a median survival time of 3.5weeks. The release of G-CSF and TNF-α from lymphoma cells may associate with ALCL presenting with PL, leading to cytokine crisis and even poorer prognosis.
AB - Anaplastic large cell lymphoma (ALCL) is a type of T-cell lymphoma with a relatively favorable prognosis. However, a certain group of ALCLs is highly aggressive, featuring paraneoplastic leukocytosis (PL) in clinical presentation. The present study evaluated five cases of ALCL presenting with PL, including four men and one woman, with a median age of 58years. All cases revealed leukocytosis with a range from 15.3 to 112.9×10 3/μL. Five (100%) and 4 (80%) cases demonstrated immunoreactivity for granulocyte-colony-stimulating factor (G-CSF) and tumor necrosis factor-alpha (TNF-α), respectively. There were significant differences in the expression of G-CSF and TNF-α between ALCL cases with or without PL (p<0.05 for both). The prognosis of ALCL patients with PL was poor. Four of five patients (80%) died of the disease within a median survival time of 3.5weeks. The release of G-CSF and TNF-α from lymphoma cells may associate with ALCL presenting with PL, leading to cytokine crisis and even poorer prognosis.
KW - ALK
KW - Anaplastic large cell lymphoma
KW - G-CSF
KW - Paraneoplastic leukocytosis
KW - TNF-α
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UR - http://www.scopus.com/inward/citedby.url?scp=80054089822&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0463.2011.02811.x
DO - 10.1111/j.1600-0463.2011.02811.x
M3 - Article
VL - 119
SP - 794
EP - 801
JO - Acta pathologica et microbiologica Scandinavica
JF - Acta pathologica et microbiologica Scandinavica
SN - 0365-5555
IS - 11
ER -