Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process

H. W. Fang, S. M. Hsu, J. V. Sengers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Biophysical principles were applied to calculate the maximum number of ultra-high molecular weight polyethylene (UHMWPE) particles that can be phagocytosed for various size and shapes of particles. It was assumed that the particle has an ellipsoidal shape with one longer and two equal shorter axes. It was found that, with the same total particle volume, elongated particles gather more macrophage cells in the phagocytosis process. It was also found that smaller particles within the phagocytosable range induce stronger bioactivity than large particles that cannot be engulfed by the macrophage cells.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
Publication statusPublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Ultrahigh molecular weight polyethylenes
Macrophages
Bioactivity

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Fang, H. W., Hsu, S. M., & Sengers, J. V. (2004). Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).

Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process. / Fang, H. W.; Hsu, S. M.; Sengers, J. V.

Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fang, HW, Hsu, SM & Sengers, JV 2004, Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process. in Transactions - 7th World Biomaterials Congress. Transactions - 7th World Biomaterials Congress, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Fang HW, Hsu SM, Sengers JV. Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process. In Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).
Fang, H. W. ; Hsu, S. M. ; Sengers, J. V. / Analysis of UHMWPE particle shape effects on bioactivity from the physical viewpoint of phagocytosis process. Transactions - 7th World Biomaterials Congress. 2004. (Transactions - 7th World Biomaterials Congress).
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