Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA

N. Matsuura, E. Tashita, J. Yamamura, Y. Kagawa, Y. Takada

Research output: Contribution to journalArticle

Abstract

Integrin plays an important role in tumor metastasis through its interaction with extracellular matrix and endothelial cell. We have examined the role of each integrin in tumor metastasis by using transfection of integrin cDNA into various cells. Transfection of integrin alpha 2 subunit into RD cells, human rhabdomyosarcoma cells which do not express integrin alpha 2 beta 1, potentiated the frequency of metastases in various organs; lung, bone, adrenal gland, lymph node. alpha 4-transfectant of Chinese hamster ovary (CHO) cells, which do not have alpha 4 beta 1 on the cell surface, metastasized to bone through its interaction with VCAM-1 in the bone marrow stroma cells. On the other hand, alpha 5-transfectant of CHO cells was much less tumorgenic than parent CHO cells. These data suggest integrin influence tumor metastasis sometimes favorably and sometimes unfavorably according to the activity and the balance of various integrins.

Original languageEnglish
Pages (from-to)1643-1647
Number of pages5
JournalNippon rinsho. Japanese journal of clinical medicine
Volume53
Issue number7
Publication statusPublished - Jul 1995
Externally publishedYes

Fingerprint

Integrins
Transfection
Complementary DNA
Neoplasm Metastasis
Cricetulus
Neoplasms
Integrin alpha Chains
Ovary
Bone and Bones
Rhabdomyosarcoma
Vascular Cell Adhesion Molecule-1
Adrenal Glands
Bone Marrow Cells
Extracellular Matrix
Endothelial Cells
Lymph Nodes
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Matsuura, N., Tashita, E., Yamamura, J., Kagawa, Y., & Takada, Y. (1995). Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA. Nippon rinsho. Japanese journal of clinical medicine, 53(7), 1643-1647.

Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA. / Matsuura, N.; Tashita, E.; Yamamura, J.; Kagawa, Y.; Takada, Y.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 53, No. 7, 07.1995, p. 1643-1647.

Research output: Contribution to journalArticle

Matsuura, N, Tashita, E, Yamamura, J, Kagawa, Y & Takada, Y 1995, 'Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA', Nippon rinsho. Japanese journal of clinical medicine, vol. 53, no. 7, pp. 1643-1647.
Matsuura, N. ; Tashita, E. ; Yamamura, J. ; Kagawa, Y. ; Takada, Y. / Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA. In: Nippon rinsho. Japanese journal of clinical medicine. 1995 ; Vol. 53, No. 7. pp. 1643-1647.
@article{854dac485d4a4968b4f9319c98008ee6,
title = "Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA",
abstract = "Integrin plays an important role in tumor metastasis through its interaction with extracellular matrix and endothelial cell. We have examined the role of each integrin in tumor metastasis by using transfection of integrin cDNA into various cells. Transfection of integrin alpha 2 subunit into RD cells, human rhabdomyosarcoma cells which do not express integrin alpha 2 beta 1, potentiated the frequency of metastases in various organs; lung, bone, adrenal gland, lymph node. alpha 4-transfectant of Chinese hamster ovary (CHO) cells, which do not have alpha 4 beta 1 on the cell surface, metastasized to bone through its interaction with VCAM-1 in the bone marrow stroma cells. On the other hand, alpha 5-transfectant of CHO cells was much less tumorgenic than parent CHO cells. These data suggest integrin influence tumor metastasis sometimes favorably and sometimes unfavorably according to the activity and the balance of various integrins.",
author = "N. Matsuura and E. Tashita and J. Yamamura and Y. Kagawa and Y. Takada",
year = "1995",
month = "7",
language = "English",
volume = "53",
pages = "1643--1647",
journal = "Nippon rinsho. Japanese journal of clinical medicine",
issn = "0047-1852",
publisher = "Nipponrinsho Co., Inc.",
number = "7",

}

TY - JOUR

T1 - Analysis of the mechanism of tumor metastasis by the transfection of integrin cDNA

AU - Matsuura, N.

AU - Tashita, E.

AU - Yamamura, J.

AU - Kagawa, Y.

AU - Takada, Y.

PY - 1995/7

Y1 - 1995/7

N2 - Integrin plays an important role in tumor metastasis through its interaction with extracellular matrix and endothelial cell. We have examined the role of each integrin in tumor metastasis by using transfection of integrin cDNA into various cells. Transfection of integrin alpha 2 subunit into RD cells, human rhabdomyosarcoma cells which do not express integrin alpha 2 beta 1, potentiated the frequency of metastases in various organs; lung, bone, adrenal gland, lymph node. alpha 4-transfectant of Chinese hamster ovary (CHO) cells, which do not have alpha 4 beta 1 on the cell surface, metastasized to bone through its interaction with VCAM-1 in the bone marrow stroma cells. On the other hand, alpha 5-transfectant of CHO cells was much less tumorgenic than parent CHO cells. These data suggest integrin influence tumor metastasis sometimes favorably and sometimes unfavorably according to the activity and the balance of various integrins.

AB - Integrin plays an important role in tumor metastasis through its interaction with extracellular matrix and endothelial cell. We have examined the role of each integrin in tumor metastasis by using transfection of integrin cDNA into various cells. Transfection of integrin alpha 2 subunit into RD cells, human rhabdomyosarcoma cells which do not express integrin alpha 2 beta 1, potentiated the frequency of metastases in various organs; lung, bone, adrenal gland, lymph node. alpha 4-transfectant of Chinese hamster ovary (CHO) cells, which do not have alpha 4 beta 1 on the cell surface, metastasized to bone through its interaction with VCAM-1 in the bone marrow stroma cells. On the other hand, alpha 5-transfectant of CHO cells was much less tumorgenic than parent CHO cells. These data suggest integrin influence tumor metastasis sometimes favorably and sometimes unfavorably according to the activity and the balance of various integrins.

UR - http://www.scopus.com/inward/record.url?scp=0029335743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029335743&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 1643

EP - 1647

JO - Nippon rinsho. Japanese journal of clinical medicine

JF - Nippon rinsho. Japanese journal of clinical medicine

SN - 0047-1852

IS - 7

ER -