Analysis of risk factors for central venous port failure in cancer patients

Ching Chuan Hsieh, Hsu Huei Weng, Wen Shih Huang, Wen Ke Wang, Chiung Lun Kao, Ming Shian Lu, Chia Siu Wang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and open-ended catheter use were significant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically significant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a significant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, open-ended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.

Original languageEnglish
Pages (from-to)4709-4714
Number of pages6
JournalWorld Journal of Gastroenterology
Volume15
Issue number37
DOIs
Publication statusPublished - Dec 16 2009
Externally publishedYes

Fingerprint

Catheters
Neoplasms
Equipment and Supplies
Thrombosis
Multivariate Analysis
Infection
Equipment Failure
Survival
Proportional Hazards Models
Statistical Factor Analysis
Cohort Studies
Survival Rate
Drug Therapy

Keywords

  • Cancer patient
  • Central venous port
  • Chemotherapy
  • Multivariate analysis
  • Risk factor

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Hsieh, C. C., Weng, H. H., Huang, W. S., Wang, W. K., Kao, C. L., Lu, M. S., & Wang, C. S. (2009). Analysis of risk factors for central venous port failure in cancer patients. World Journal of Gastroenterology, 15(37), 4709-4714. https://doi.org/10.3748/wjg.15.4709

Analysis of risk factors for central venous port failure in cancer patients. / Hsieh, Ching Chuan; Weng, Hsu Huei; Huang, Wen Shih; Wang, Wen Ke; Kao, Chiung Lun; Lu, Ming Shian; Wang, Chia Siu.

In: World Journal of Gastroenterology, Vol. 15, No. 37, 16.12.2009, p. 4709-4714.

Research output: Contribution to journalArticle

Hsieh, CC, Weng, HH, Huang, WS, Wang, WK, Kao, CL, Lu, MS & Wang, CS 2009, 'Analysis of risk factors for central venous port failure in cancer patients', World Journal of Gastroenterology, vol. 15, no. 37, pp. 4709-4714. https://doi.org/10.3748/wjg.15.4709
Hsieh, Ching Chuan ; Weng, Hsu Huei ; Huang, Wen Shih ; Wang, Wen Ke ; Kao, Chiung Lun ; Lu, Ming Shian ; Wang, Chia Siu. / Analysis of risk factors for central venous port failure in cancer patients. In: World Journal of Gastroenterology. 2009 ; Vol. 15, No. 37. pp. 4709-4714.
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AU - Lu, Ming Shian

AU - Wang, Chia Siu

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N2 - AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and open-ended catheter use were significant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically significant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a significant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, open-ended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.

AB - AIM: To analyze the risk factors for central port failure in cancer patients administered chemotherapy, using univariate and multivariate analyses. METHODS: A total of 1348 totally implantable venous access devices (TIVADs) were implanted into 1280 cancer patients in this cohort study. A Cox proportional hazard model was applied to analyze risk factors for failure of TIVADs. Log-rank test was used to compare actuarial survival rates. Infection, thrombosis, and surgical complication rates (χ2 test or Fisher's exact test) were compared in relation to the risk factors. RESULTS: Increasing age, male gender and open-ended catheter use were significant risk factors reducing survival of TIVADs as determined by univariate and multivariate analyses. Hematogenous malignancy decreased the survival time of TIVADs; this reduction was not statistically significant by univariate analysis [hazard ratio (HR) = 1.336, 95% CI: 0.966-1.849, P = 0.080)]. However, it became a significant risk factor by multivariate analysis (HR = 1.499, 95% CI: 1.079-2.083, P = 0.016) when correlated with variables of age, sex and catheter type. Close-ended (Groshong) catheters had a lower thrombosis rate than open-ended catheters (2.5% vs 5%, P = 0.015). Hematogenous malignancy had higher infection rates than solid malignancy (10.5% vs 2.5%, P < 0.001). CONCLUSION: Increasing age, male gender, open-ended catheters and hematogenous malignancy were risk factors for TIVAD failure. Close-ended catheters had lower thrombosis rates and hematogenous malignancy had higher infection rates.

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