Analysis of host versus tumor interaction in cancer patients

Opposing role of transforming growth factor-β1 and interleukin-6 in the development of in situ tumor immunity

Jy Ping Tsai, Hsin Wei Chen, Mei Lien Cheng, Hsiung Kun Liu, Yi Ping Lee, Chia Ling Hsieh, Kwen Tay Luh, Chew Wun Wu, Li Han Hsu, Tsu Yi Chao, Wen Hua Wang, Chung Ming Chang, Chou Chik Ting

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A different degree of immunodeficiency is often found at tumor sites in cancer patients. At the late stage many patients develop malignant effusion that contains large numbers of tumor cells and host immune cells that constantly interact with each other. These sites may provide an ideal model to examine in situ anti-tumor immunity. The T cells in effusion were found to be immunodeficient, which suggested a defective anti-tumor cytotoxic T lymphocytes response. To pursue the mechanism for the T cell deficiency, we determined the production of immunomodulating cytokines in the effusion and detected the presence of transforming growth factor-β1 (TGFβ), prostaglandin E2, IL-6, IL-10, and IFNγ. There was no detectable IL-2, IL-4, IL-12, or TNFα. The most prominent feature was the presence of TGFβ and IL-6 at a very high level. Thus, the possible role of these two cytokines on T cell competence was further determined. TGFβ was found to induce T cell anergy and reduced the production of perforin in T killer cells and their lytic activity. These events lead to the induction of peripheral T cell tolerance with profound T cell deficiency. IL-6 did not affect perforin production or cytolytic activity of the T killer cells. But the CD4+CD25+ regulatory T cells (TR) that were often employed by TGFβ to suppress T cell response were reduced in the malignant effusion, consistent with the fact that IL-6 down-regulates TR and this may represent the host's vigorous response to the tumor's subversion. These results show that TGFβ and IL-6 might play pivotal but opposing roles in the host-tumor interaction that, together with other immunomodulating components, determines the outcome for the development of local tumor immunity.

Original languageEnglish
Pages (from-to)661-671
Number of pages11
JournalImmunobiology
Volume210
Issue number9
DOIs
Publication statusPublished - Nov 15 2005
Externally publishedYes

Fingerprint

Transforming Growth Factors
Immunity
Interleukin-6
T-Lymphocytes
Neoplasms
Perforin
Cytokines
Cytotoxic T-Lymphocytes
Regulatory T-Lymphocytes
Interleukin-12
Dinoprostone
Interleukin-4
Interleukin-10
Mental Competency
Interleukin-2
Down-Regulation
Cell Count

Keywords

  • Host-tumor interaction
  • IL-6
  • In situ immunity
  • TGFβ

ASJC Scopus subject areas

  • Immunology

Cite this

Analysis of host versus tumor interaction in cancer patients : Opposing role of transforming growth factor-β1 and interleukin-6 in the development of in situ tumor immunity. / Tsai, Jy Ping; Chen, Hsin Wei; Cheng, Mei Lien; Liu, Hsiung Kun; Lee, Yi Ping; Hsieh, Chia Ling; Luh, Kwen Tay; Wu, Chew Wun; Hsu, Li Han; Chao, Tsu Yi; Wang, Wen Hua; Chang, Chung Ming; Ting, Chou Chik.

In: Immunobiology, Vol. 210, No. 9, 15.11.2005, p. 661-671.

Research output: Contribution to journalArticle

Tsai, Jy Ping ; Chen, Hsin Wei ; Cheng, Mei Lien ; Liu, Hsiung Kun ; Lee, Yi Ping ; Hsieh, Chia Ling ; Luh, Kwen Tay ; Wu, Chew Wun ; Hsu, Li Han ; Chao, Tsu Yi ; Wang, Wen Hua ; Chang, Chung Ming ; Ting, Chou Chik. / Analysis of host versus tumor interaction in cancer patients : Opposing role of transforming growth factor-β1 and interleukin-6 in the development of in situ tumor immunity. In: Immunobiology. 2005 ; Vol. 210, No. 9. pp. 661-671.
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AU - Cheng, Mei Lien

AU - Liu, Hsiung Kun

AU - Lee, Yi Ping

AU - Hsieh, Chia Ling

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