Analysis of erythrocyte C4d to complement receptor 1 ratio: Use in distinguishing between infection and flare-up in febrile patients with systemic lupus erythematosus

Chen Hung Chen, Shun Ban Tai, Hsiang Cheng Chen, Deng Ho Yang, Ming Yieh Peng, Yuh Feng Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and

Original languageEnglish
Article number939783
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

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Complement C1
Complement Receptors
Systemic Lupus Erythematosus
C-Reactive Protein
Fever
Erythrocytes
Biomarkers
Infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Analysis of erythrocyte C4d to complement receptor 1 ratio : Use in distinguishing between infection and flare-up in febrile patients with systemic lupus erythematosus. / Chen, Chen Hung; Tai, Shun Ban; Chen, Hsiang Cheng; Yang, Deng Ho; Peng, Ming Yieh; Lin, Yuh Feng.

In: BioMed Research International, Vol. 2015, 939783, 2015.

Research output: Contribution to journalArticle

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abstract = "Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91{\%} sensitive and 100.0{\%} specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and",
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T1 - Analysis of erythrocyte C4d to complement receptor 1 ratio

T2 - Use in distinguishing between infection and flare-up in febrile patients with systemic lupus erythematosus

AU - Chen, Chen Hung

AU - Tai, Shun Ban

AU - Chen, Hsiang Cheng

AU - Yang, Deng Ho

AU - Peng, Ming Yieh

AU - Lin, Yuh Feng

PY - 2015

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N2 - Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and

AB - Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and

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