Abstract
Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and
| Original language | English |
|---|---|
| Article number | 939783 |
| Journal | BioMed Research International |
| Volume | 2015 |
| DOIs | |
| Publication status | Published - 2015 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
Cite this
Analysis of erythrocyte C4d to complement receptor 1 ratio : Use in distinguishing between infection and flare-up in febrile patients with systemic lupus erythematosus. / Chen, Chen Hung; Tai, Shun Ban; Chen, Hsiang Cheng; Yang, Deng Ho; Peng, Ming Yieh; Lin, Yuh Feng.
In: BioMed Research International, Vol. 2015, 939783, 2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of erythrocyte C4d to complement receptor 1 ratio
T2 - Use in distinguishing between infection and flare-up in febrile patients with systemic lupus erythematosus
AU - Chen, Chen Hung
AU - Tai, Shun Ban
AU - Chen, Hsiang Cheng
AU - Yang, Deng Ho
AU - Peng, Ming Yieh
AU - Lin, Yuh Feng
PY - 2015
Y1 - 2015
N2 - Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and
AB - Objective. Fever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients. Methods. We enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course. Results. Among the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of 4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and
UR - http://www.scopus.com/inward/record.url?scp=84939126854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939126854&partnerID=8YFLogxK
U2 - 10.1155/2015/939783
DO - 10.1155/2015/939783
M3 - Article
C2 - 26273660
AN - SCOPUS:84939126854
VL - 2015
JO - BioMed Research International
JF - BioMed Research International
SN - 2314-6133
M1 - 939783
ER -