Analysis of cell ratio and drug concentration influence in feigning lung cancer model

Kuo Wei Chang, Tse Shao Chen, Shilpa Sivashankar, Ming Yan Chen, Kang Yun Lee, Cheng Hsien Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here presented is an integrated drug testing system based on a mimetic lung tissue pattern of in vitro targeted therapy testing. The integrated targeted therapy testing system consists of continuous concentration gradient platform and dielectrophoretic (DEP) cell patterning chambers. DEP forces are based on polarity difference to manipulate heterogeneous cells for mimicking the inherent lung morphology and increasing the cell-cell interaction. The multiplexed microchannels allow for simultaneous administration of multiple drug doses to functional lung cancer cells while an incorporated concentration gradient enables the in vitro dose-dependent drug responses to predict in vivo hepatotoxicity.

Original languageEnglish
Title of host publication2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
Pages369-372
Number of pages4
DOIs
Publication statusPublished - 2013
Externally publishedYes
Event2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 - Barcelona, Spain
Duration: Jun 16 2013Jun 20 2013

Other

Other2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013
CountrySpain
CityBarcelona
Period6/16/136/20/13

Keywords

  • dielectrophoretic (DEP)
  • gradient microchannel
  • Lung cancer
  • patterned
  • targeted therapy

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

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  • Cite this

    Chang, K. W., Chen, T. S., Sivashankar, S., Chen, M. Y., Lee, K. Y., & Liu, C. H. (2013). Analysis of cell ratio and drug concentration influence in feigning lung cancer model. In 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 (pp. 369-372). [6626779] https://doi.org/10.1109/Transducers.2013.6626779