Analgesic Effects of Orexins

Jen Kun Cheng, Ling-Ling Hwang, Robert Chang Chih Chou, Lih-Chu Chiou

Research output: Contribution to journalArticlepeer-review

Abstract

Orexin A and B (hypocretin 1 and 2) are novel hypothalamic peptides and two receptor subtypes, OXjR and OX2 R, were identified. Orexins are implicated in hyper-phagia, arousal, and neuroendocrine and auto-nomic regulations. Recently, orexins were found to be antinociceptive supraspinally and spinally but sympathetically stimulating. This review summarizes the analgesic effects of orexins reported in acute, inflammatory, and neuropathic pain animal models. The antinociceptive effects of orexins are mediated by OXjR, but not opioidreceptors. Purinergic P2X and glycine receptors are supported to be involved in the intrathecal orexin-induced antiallodynia. Endogenous orexins may play a protective role after nociceptive Stimulation.
Original languageEnglish
Pages (from-to)47-53
JournalJournal of Neuropathic Pain & Symptom Palliation
Volume1
Issue number1
Publication statusPublished - 2011

Keywords

  • Orexins
  • pain
  • antinociceptive
  • antiallodynia
  • orexin receptors
  • analgesia

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