An update on mesoporous silica nanoparticle applications in nanomedicine

Elham Rastegari, Yu Jer Hsiao, Wei Yi Lai, Yun Hsien Lai, Tien Chun Yang, Shih Jen Chen, Pin I. Huang, Shih Hwa Chiou, Chung Yuan Mou, Yueh Chien

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

Original languageEnglish
Article number1067
JournalPharmaceutics
Volume13
Issue number7
DOIs
Publication statusPublished - Jul 2021
Externally publishedYes

Keywords

  • Bioimaging
  • Cancer therapy
  • Mesoporous silica nanoparticles
  • Stem cell research
  • Tissue engineering

ASJC Scopus subject areas

  • Pharmaceutical Science

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