An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training

Zong Yan Cai, Cheng Chen Hsu, Mei Chich Hsu, Mao Shung Huang, Chao Pin Yang, Yung Yu Tsai, Borcherng Su

Research output: Contribution to journalArticle

Abstract

Background and Puepose: The molecular pathological markers of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 alpha (HIF-1α), von Hippel-Lindau tumor suppressor protein (VHL) and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC- 1α), are recently linked in the regulation of oxygen availability. The purpose of this study was to investigate these molecular markers of the cardiomyocyte adapt to moderate endurance training. Materials and Methods: we performed immunohistochemical staining coupled with image analysis for quantification in male Sprague- Dawley rat myocardium that had been trained on treadmill running at 20 m/min for 30 min on a 0% grade, for 3 days/wk. for 4 weeks (4WT) or 8 weeks (8WT) and control rats for 4 weeks (4WC) or 8 weeks (8WC) (n=6, respectively). Results: Training led to no significant alteration in HIF-1α content. Interestingly, a lower VHL content and higher VEGF contents were detected in the trained groups compared with their control counterparts (p

Original languageEnglish
Pages (from-to)1440-1448
Number of pages9
JournalHealthMED
Volume5
Issue number6
Publication statusPublished - 2011

Fingerprint

Hypoxia-Inducible Factor 1
Cardiac Myocytes
Vascular Endothelial Growth Factor A
Von Hippel-Lindau Tumor Suppressor Protein
Oxygen
Running
Sprague Dawley Rats
Myocardium
Staining and Labeling
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha

Keywords

  • HIF-1α
  • PGC-1α
  • VEGF
  • VHL

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cai, Z. Y., Hsu, C. C., Hsu, M. C., Huang, M. S., Yang, C. P., Tsai, Y. Y., & Su, B. (2011). An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training. HealthMED, 5(6), 1440-1448.

An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training. / Cai, Zong Yan; Hsu, Cheng Chen; Hsu, Mei Chich; Huang, Mao Shung; Yang, Chao Pin; Tsai, Yung Yu; Su, Borcherng.

In: HealthMED, Vol. 5, No. 6, 2011, p. 1440-1448.

Research output: Contribution to journalArticle

Cai, ZY, Hsu, CC, Hsu, MC, Huang, MS, Yang, CP, Tsai, YY & Su, B 2011, 'An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training', HealthMED, vol. 5, no. 6, pp. 1440-1448.
Cai ZY, Hsu CC, Hsu MC, Huang MS, Yang CP, Tsai YY et al. An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training. HealthMED. 2011;5(6):1440-1448.
Cai, Zong Yan ; Hsu, Cheng Chen ; Hsu, Mei Chich ; Huang, Mao Shung ; Yang, Chao Pin ; Tsai, Yung Yu ; Su, Borcherng. / An oxygen-sensing signal cascade of cardiomyocyte adaptations to moderate endurance training. In: HealthMED. 2011 ; Vol. 5, No. 6. pp. 1440-1448.
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