An overview of the rare parotid gland cancer

Kimberley Ho, Helen Lin, David K. Ann, Peiguo G. Chu, Yun Yen

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Cancer of the parotid gland is relatively rare, but carries poor prognosis owing to its prevailing distant metastases. In addition to the disease's basic epidemiology and pathology, we review some current discoveries of its tumorigenesis molecular mechanism. Based on published salivary gland cancer clinical trial data, non-surgical antitumor efficacies amongst a range of chemotherapy, radiation, and concurrent therapy regimens are compared. We also present the current development status of novel radiation therapy and targeted therapeutics, focusing on intensity-modulated radiation therapy (IMRT), and epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) blockages, which are showing promise for improving parotid gland cancer management.

Original languageEnglish
Article number40
JournalHead and Neck Oncology
Volume3
Issue number1
DOIs
Publication statusPublished - Sep 21 2011
Externally publishedYes

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Keywords

  • endosomal sorting complexes required for transport
  • epidermal growth factor receptor
  • multi-vesicular bodies
  • Parotid gland cancer
  • salivary gland cancer
  • targeted therapeutics
  • vacuolar protein sorting-associated protein 4B
  • vascular endothelial growth factor

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Oncology

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