An outcome analysis of self-expandable metallic stents in central airway obstruction: A cohort study

Fu Tsai Chung, Hao Cheng Chen, Chun Liang Chou, Chih Teng Yu, Chih Hsi Kuo, Han Pin Kuo, Shu Min Lin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Background: Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.Methods: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.Results: The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Conclusions: Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.

Original languageEnglish
Article number46
JournalJournal of Cardiothoracic Surgery
Volume6
Issue number1
DOIs
Publication statusPublished - Apr 8 2011
Externally publishedYes

Fingerprint

Airway Obstruction
Cohort Studies
Self Expandable Metallic Stents
Granulation Tissue
Forced Expiratory Volume
Tertiary Care Centers
Neoplasms
Smoking

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

An outcome analysis of self-expandable metallic stents in central airway obstruction : A cohort study. / Chung, Fu Tsai; Chen, Hao Cheng; Chou, Chun Liang; Yu, Chih Teng; Kuo, Chih Hsi; Kuo, Han Pin; Lin, Shu Min.

In: Journal of Cardiothoracic Surgery, Vol. 6, No. 1, 46, 08.04.2011.

Research output: Contribution to journalArticle

Chung, Fu Tsai ; Chen, Hao Cheng ; Chou, Chun Liang ; Yu, Chih Teng ; Kuo, Chih Hsi ; Kuo, Han Pin ; Lin, Shu Min. / An outcome analysis of self-expandable metallic stents in central airway obstruction : A cohort study. In: Journal of Cardiothoracic Surgery. 2011 ; Vol. 6, No. 1.
@article{39ce8bd5334e480e96645c68fb764b0a,
title = "An outcome analysis of self-expandable metallic stents in central airway obstruction: A cohort study",
abstract = "Background: Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.Methods: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.Results: The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62{\%} vs. 90{\%}; p < 0.0001), smoking (47{\%} vs. 85{\%}; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2{\%} vs. 94.7{\%}; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7{\%} vs. 51.6{\%}; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2{\%} vs. 21.1{\%}; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100{\%}, 81.25{\%}, and 85{\%} of patients, respectively.Conclusions: Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.",
author = "Chung, {Fu Tsai} and Chen, {Hao Cheng} and Chou, {Chun Liang} and Yu, {Chih Teng} and Kuo, {Chih Hsi} and Kuo, {Han Pin} and Lin, {Shu Min}",
year = "2011",
month = "4",
day = "8",
doi = "10.1186/1749-8090-6-46",
language = "English",
volume = "6",
journal = "Journal of Cardiothoracic Surgery",
issn = "1749-8090",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - An outcome analysis of self-expandable metallic stents in central airway obstruction

T2 - A cohort study

AU - Chung, Fu Tsai

AU - Chen, Hao Cheng

AU - Chou, Chun Liang

AU - Yu, Chih Teng

AU - Kuo, Chih Hsi

AU - Kuo, Han Pin

AU - Lin, Shu Min

PY - 2011/4/8

Y1 - 2011/4/8

N2 - Background: Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.Methods: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.Results: The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Conclusions: Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.

AB - Background: Self-expandable metallic stents (SEMSs) have provided satisfactory management of central airway obstruction. However, the long-term benefits and complications of this management modality in patients with benign and malignant obstructing lesions after SEMS placement are unclear. We performed this cohort study to analyze the outcomes of Ultraflex SEMSs in patients with tracheobronchial diseases.Methods: Of 149 patients, 72 with benign and 77 with malignant tracheobronchial disease received 211 SEMSs (benign, 116; malignant, 95) and were retrospectively reviewed in a tertiary hospital.Results: The baseline characteristics of patients who received SEMS implantation for benign conditions and those who underwent implantation for malignant conditions were significantly different. These characteristics included age (mean, 63.9 vs. 58; p < 0.01), gender (male, 62% vs. 90%; p < 0.0001), smoking (47% vs. 85%; p < 0.0001), forced expiratory volume in 1 second (mean, 0.9 vs. 1.47 L/s; p < 0.0001), follow-up days after SEMS implantation (median; 429 vs. 57; p < 0.0001), and use of covered SEMS (36.2% vs. 94.7%; p < 0.0001). Symptoms improved more after SEMS implantation in patients with benign conditions than in those with malignant conditions (76.7% vs. 51.6%; p < 0.0001). The overall complication rate after SEMS implantation in patients with benign conditions was higher than that in patients with malignancy (42.2% vs. 21.1%; p = 0.001). Successful management of SEMS migration, granulation tissue formation, and SEMS fracture occurred in 100%, 81.25%, and 85% of patients, respectively.Conclusions: Patients who received SEMS implantation owing to benign conditions had worse lung function and were older than those who received SEMS for malignancies. There was higher complication rate in patients with benign conditions after a longer follow-up period owing to the nature of the underlying diseases.

UR - http://www.scopus.com/inward/record.url?scp=79953750077&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953750077&partnerID=8YFLogxK

U2 - 10.1186/1749-8090-6-46

DO - 10.1186/1749-8090-6-46

M3 - Article

C2 - 21477303

AN - SCOPUS:79953750077

VL - 6

JO - Journal of Cardiothoracic Surgery

JF - Journal of Cardiothoracic Surgery

SN - 1749-8090

IS - 1

M1 - 46

ER -