An outbreak of meningitis caused by Angiostrongylus cantonensis in Kaohsiung

T. H. Tsai, Y. C. Liu, S. R. Wann, W. R. Lin, S. S J Lee, H. H. Lin, Y. S. Chen, M. Y. Yen, C. M. Yen

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Eight Thai laborers developed meningitis after eating raw snails (Ampullarium canaliculatus) during the period from September 27 to October 6, 1998. The diagnosis of Angiostrongylus cantonensis infection was established in all patients by serologic studies of serum and cerebral spinal fluid (CSF). Clinical manifestations included meningitis, radiculitis and cranial nerve palsy. Symptoms included fever, headache, orbital pain, gastrointestinal upset, hyperesthesia, muscle weakness, skin rash and diplopia. Laboratory abnormalities included peripheral eosinophilia, CSF eosinophilia, transient elevation of liver enzymes and creatinine phosphokinase, elevation of IgE. No space occupying lesions were detected by magnetic resonance imaging of the brain. None of the patients developed severe sequelae during the 6-month follow-up except for occasional headache in one patient. This report also provides evidence that third stage larvae were present in the intermediate host, A. canaliculatus, which the laborers had eaten.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalJournal of Microbiology, Immunology and Infection
Issue number1
Publication statusPublished - 2001
Externally publishedYes


  • Ampullarium canaliculatus
  • Angiostrongylus cantonensis
  • Meningitis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)


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