An innovative bioceramic bone graft with platelet-rich plasma for rapid bone healing and regeneration in a rabbit model

Syamsiah Syam, Chun Wei Chang, Wen Chien Lan, Keng Liang Ou, Bai Hung Huang, Yu Yeong Lin, Takashi Saito, Hsin Yu Tsai, Yen Chun Chuo, Tzu Sen Yang, Chung Ming Liu, Ping Jen Hou

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.

Original languageEnglish
Article number5271
JournalApplied Sciences (Switzerland)
Volume11
Issue number11
DOIs
Publication statusPublished - Jun 1 2021

Keywords

  • Bioceramic bone graft
  • Bone healing
  • Bone regeneration
  • Platelet-rich plasma
  • α-calcium sulfate hemihydrate

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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