An in vivo evaluation of a novel malleable composite scaffold (polypropylene carbonate/ poly(D-lactic acid) /tricalcium phosphate elastic composites) for bone defect repair

Guang Wei Chang, Ching Li Tseng, Yuan Sheng Tzeng, Tim Mo Chen, Hsu Wei Fang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

An osteoconductive scaffold can facilitate bone defect repair. In this study, a novel elastic porous composite comprising poly(propylene carbonate) (PPC), poly(D-lactic acid) (PDLA), and β-tricalcium phosphate (β-TCP) was prepared as an osteoconductive scaffold. A salt-leaching method is a non-solvent and easily operated method used to mold up the porous scaffolds. The cylinder scaffold was implanted into a 5. mm in diameter and 10. mm in height rabbit femur condyle defect in 6 rabbits. 4 other rabbits with the same defect that did not have the scaffold implanted served as a control group. Rabbits bone tissue specimens were retrieved at 4 and 12 weeks after surgery. 3 reconstructed and 2 unreconstructed rabbits were examined at each time point. The assessments included a computed tomography (CT) scan and a histological examination. The results demonstrate that a PDT porous scaffold made at a PPC/PDLA/TCP weight ratio of 90/8/2 is (1) biocompatible, yielding a positive cell culture study and minimal inflammatory response in vivo; (2) malleable, such that the scaffold can be molded into the bone defect easily without fracturing; and (3) biodegradable and osteoconductive, promoting the progressive formation of new bone into the bone defect. These results indicated that combination of this scaffold with osteoinductive agents such as bone morphogenetic protein, demineralized bone matrix, or mesenchymal cells may generate new biomaterial for bone defect repair.

Original languageEnglish
JournalJournal of the Taiwan Institute of Chemical Engineers
DOIs
Publication statusAccepted/In press - 2017

Fingerprint

Lactic acid
Scaffolds
Polypropylenes
Carbonates
Lactic Acid
Bone
Phosphates
Repair
Defects
Composite materials
Bone Morphogenetic Proteins
polypropylene carbonate
tricalcium phosphate
Biocompatible Materials
Scaffolds (biology)
Cell culture
Biomaterials
Surgery
Leaching
Propylene

Keywords

  • Bone defect repair
  • Poly(lactic acid)
  • Poly(propylene carbonate)
  • β-tricalcium phosphate

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

@article{cdc166f7bfce4b34aa5539ad9f3003e7,
title = "An in vivo evaluation of a novel malleable composite scaffold (polypropylene carbonate/ poly(D-lactic acid) /tricalcium phosphate elastic composites) for bone defect repair",
abstract = "An osteoconductive scaffold can facilitate bone defect repair. In this study, a novel elastic porous composite comprising poly(propylene carbonate) (PPC), poly(D-lactic acid) (PDLA), and β-tricalcium phosphate (β-TCP) was prepared as an osteoconductive scaffold. A salt-leaching method is a non-solvent and easily operated method used to mold up the porous scaffolds. The cylinder scaffold was implanted into a 5. mm in diameter and 10. mm in height rabbit femur condyle defect in 6 rabbits. 4 other rabbits with the same defect that did not have the scaffold implanted served as a control group. Rabbits bone tissue specimens were retrieved at 4 and 12 weeks after surgery. 3 reconstructed and 2 unreconstructed rabbits were examined at each time point. The assessments included a computed tomography (CT) scan and a histological examination. The results demonstrate that a PDT porous scaffold made at a PPC/PDLA/TCP weight ratio of 90/8/2 is (1) biocompatible, yielding a positive cell culture study and minimal inflammatory response in vivo; (2) malleable, such that the scaffold can be molded into the bone defect easily without fracturing; and (3) biodegradable and osteoconductive, promoting the progressive formation of new bone into the bone defect. These results indicated that combination of this scaffold with osteoinductive agents such as bone morphogenetic protein, demineralized bone matrix, or mesenchymal cells may generate new biomaterial for bone defect repair.",
keywords = "Bone defect repair, Poly(lactic acid), Poly(propylene carbonate), β-tricalcium phosphate",
author = "Chang, {Guang Wei} and Tseng, {Ching Li} and Tzeng, {Yuan Sheng} and Chen, {Tim Mo} and Fang, {Hsu Wei}",
year = "2017",
doi = "10.1016/j.jtice.2017.06.022",
language = "English",
journal = "Journal of the Taiwan Institute of Chemical Engineers",
issn = "1876-1070",
publisher = "Taiwan Institute of Chemical Engineers",

}

TY - JOUR

T1 - An in vivo evaluation of a novel malleable composite scaffold (polypropylene carbonate/ poly(D-lactic acid) /tricalcium phosphate elastic composites) for bone defect repair

AU - Chang, Guang Wei

AU - Tseng, Ching Li

AU - Tzeng, Yuan Sheng

AU - Chen, Tim Mo

AU - Fang, Hsu Wei

PY - 2017

Y1 - 2017

N2 - An osteoconductive scaffold can facilitate bone defect repair. In this study, a novel elastic porous composite comprising poly(propylene carbonate) (PPC), poly(D-lactic acid) (PDLA), and β-tricalcium phosphate (β-TCP) was prepared as an osteoconductive scaffold. A salt-leaching method is a non-solvent and easily operated method used to mold up the porous scaffolds. The cylinder scaffold was implanted into a 5. mm in diameter and 10. mm in height rabbit femur condyle defect in 6 rabbits. 4 other rabbits with the same defect that did not have the scaffold implanted served as a control group. Rabbits bone tissue specimens were retrieved at 4 and 12 weeks after surgery. 3 reconstructed and 2 unreconstructed rabbits were examined at each time point. The assessments included a computed tomography (CT) scan and a histological examination. The results demonstrate that a PDT porous scaffold made at a PPC/PDLA/TCP weight ratio of 90/8/2 is (1) biocompatible, yielding a positive cell culture study and minimal inflammatory response in vivo; (2) malleable, such that the scaffold can be molded into the bone defect easily without fracturing; and (3) biodegradable and osteoconductive, promoting the progressive formation of new bone into the bone defect. These results indicated that combination of this scaffold with osteoinductive agents such as bone morphogenetic protein, demineralized bone matrix, or mesenchymal cells may generate new biomaterial for bone defect repair.

AB - An osteoconductive scaffold can facilitate bone defect repair. In this study, a novel elastic porous composite comprising poly(propylene carbonate) (PPC), poly(D-lactic acid) (PDLA), and β-tricalcium phosphate (β-TCP) was prepared as an osteoconductive scaffold. A salt-leaching method is a non-solvent and easily operated method used to mold up the porous scaffolds. The cylinder scaffold was implanted into a 5. mm in diameter and 10. mm in height rabbit femur condyle defect in 6 rabbits. 4 other rabbits with the same defect that did not have the scaffold implanted served as a control group. Rabbits bone tissue specimens were retrieved at 4 and 12 weeks after surgery. 3 reconstructed and 2 unreconstructed rabbits were examined at each time point. The assessments included a computed tomography (CT) scan and a histological examination. The results demonstrate that a PDT porous scaffold made at a PPC/PDLA/TCP weight ratio of 90/8/2 is (1) biocompatible, yielding a positive cell culture study and minimal inflammatory response in vivo; (2) malleable, such that the scaffold can be molded into the bone defect easily without fracturing; and (3) biodegradable and osteoconductive, promoting the progressive formation of new bone into the bone defect. These results indicated that combination of this scaffold with osteoinductive agents such as bone morphogenetic protein, demineralized bone matrix, or mesenchymal cells may generate new biomaterial for bone defect repair.

KW - Bone defect repair

KW - Poly(lactic acid)

KW - Poly(propylene carbonate)

KW - β-tricalcium phosphate

UR - http://www.scopus.com/inward/record.url?scp=85025099786&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85025099786&partnerID=8YFLogxK

U2 - 10.1016/j.jtice.2017.06.022

DO - 10.1016/j.jtice.2017.06.022

M3 - Article

AN - SCOPUS:85025099786

JO - Journal of the Taiwan Institute of Chemical Engineers

JF - Journal of the Taiwan Institute of Chemical Engineers

SN - 1876-1070

ER -