An in silico toxicogenomics approach for inferring potential diseases associated with maleic acid

Ying Chi Lin, Chia Chi Wang, Chun Wei Tung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Maleic acid is a multi-functional chemical widely applied in the manufacturing of polymer products including food packaging. However, the contamination of maleic acid in modified starch has raised the concerns about the effects of chronic exposure to maleic acid on human health. This study proposed a novel toxicogenomics approach for inferring functions, pathways and diseases potentially affected by maleic acid on humans by using known interactions between maleic acid and proteins. Neuronal signal transmission and cell metabolism were identified to be most influenced by maleic acid in this study. The top disease categories inferred to be associated with maleic acid were mental disorder, nervous system diseases, cardiovascular diseases, and cancers. The results from the in silico analysis showed that maleic acid could penetrate the blood-brain barrier to affect the nervous system. Several functions and pathways were further analyzed and identified to give insights into the mechanisms of maleic acid-associated diseases. The toxicogenomics approach may offer both a better understanding of the potential risks of maleic-acid exposure to humans and a direction for future toxicological investigation.

Original languageEnglish
Pages (from-to)38-44
Number of pages7
JournalChemico-Biological Interactions
Volume223
DOIs
Publication statusPublished - Nov 5 2014
Externally publishedYes

Fingerprint

Toxicogenetics
Computer Simulation
Neurology
maleic acid
Food Packaging
Nervous System Diseases
Blood-Brain Barrier
Metabolism
Mental Disorders
Starch
Toxicology
Nervous System
Packaging
Polymers
Contamination
Cardiovascular Diseases

Keywords

  • Diseases
  • In silico analysis
  • Maleic acid
  • Toxicogenomics

ASJC Scopus subject areas

  • Toxicology

Cite this

An in silico toxicogenomics approach for inferring potential diseases associated with maleic acid. / Lin, Ying Chi; Wang, Chia Chi; Tung, Chun Wei.

In: Chemico-Biological Interactions, Vol. 223, 05.11.2014, p. 38-44.

Research output: Contribution to journalArticle

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