An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

Yu-An Chen; Chen-Yu Lu; Wen-Fang Cheng; Kuan-Ting Kuo; Chen-Wei Yu; Hon-Nerng Ho; Hsin-Fu Chen; Szu-Hua Pan

doi:10.1186/s12885-022-10042-3

An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

Yu-An Chen, Chen-Yu Lu, Wen-Fang Cheng, Kuan-Ting Kuo, Chen-Wei Yu, Hon-Nerng Ho, Hsin-Fu Chen, Szu-Hua Pan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.

Original language	Chinese (Traditional)
Journal	BMC Cancer
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12885-022-10042-3
Publication status	Published - 2022
Externally published	Yes

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Access to Document

10.1186/s12885-022-10042-3

Cite this

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title = "An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids",

abstract = "Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.",

author = "Yu-An Chen and Chen-Yu Lu and Wen-Fang Cheng and Kuan-Ting Kuo and Chen-Wei Yu and Hon-Nerng Ho and Hsin-Fu Chen and Szu-Hua Pan",

year = "2022",

doi = "10.1186/s12885-022-10042-3",

language = "中文",

volume = "22",

journal = "BMC Cancer",

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number = "1",

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TY - JOUR

T1 - An experimental model for ovarian cancer: propagation of ovarian cancer initiating cells and generation of ovarian cancer organoids

AU - Chen, Yu-An

AU - Lu, Chen-Yu

AU - Cheng, Wen-Fang

AU - Kuo, Kuan-Ting

AU - Yu, Chen-Wei

AU - Ho, Hon-Nerng

AU - Chen, Hsin-Fu

AU - Pan, Szu-Hua

PY - 2022

Y1 - 2022

N2 - Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.

AB - Ovarian cancer (OC) is the most lethal gynecological cancer due to the recurrence of drug-resistance. Cancer initiating cells (CICs) are proposed to be responsible for the aggressiveness of OC. The rarity and difficulty of in vitro long-term cultivation of CICs challenge the development of CIC-targeting therapeutics. Reprogramming cancer cells into induced cancer initiating cell (iCICs) could be an approach to solve these. Several inducible CICs have been acquired by activating the expression of stemness genes in different cancer cells. However, few reports have demonstrated the feasibility in OC.

U2 - 10.1186/s12885-022-10042-3

DO - 10.1186/s12885-022-10042-3

M3 - 文章

SN - 1471-2407

VL - 22

JO - BMC Cancer

JF - BMC Cancer

IS - 1

ER -