An evaluation of fatty acid-CoA ligase 4 in breast cancer

Chin Hua Tsai, Shyr Ming Sheen-Chen, Chun Ying Huang, Ying Ju Chen, Shun Yu Chi, Sheung Fat Ko, Yi Wei Lee, Jiun Lung Liang, Hsien Wen Hsu, Eng Yen Huang, Hui Chun Chen, Chao Cheng Huang, Kung Ming Rau, Rei Ping Tang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Fatty acid-CoA ligase 4 (FACL4) has been detected in various types of tumors. However, there is still very limited information about the role of FACL4 in breast cancer. Tissue microarray (TMA ) technique analyzes thousands of specimens in a parallel fashion with minimal damage to the original blocks. This study was designed with the application of TMA to analyze the FACL4 status in breast cancer. Materials and Methods: Archival tissue specimens from 102 patients with primary invasive breast cancer were selected and FACL4 expression was analyzed by immunhistochemical staining with TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. Results: As shown my multivariate analysis, TNM stage was significantly related to the overall five-year survival rate. Nevertheless, FACL4 expression failed to have any significant relationship to overall five-year survival. Conclusion: Immuno-histochemical staining with TMA was convenient and feasible for the analysis of FACL4 expression status in breast cancer. Our preliminary results showed that FACL4 expression had no significant prognostic value in breast cancer.

Original languageEnglish
Pages (from-to)1239-1243
Number of pages5
JournalAnticancer Research
Volume34
Issue number3
Publication statusPublished - Mar 1 2014
Externally publishedYes

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Coenzyme A
Ligases
Fatty Acids
Breast Neoplasms
Tissue Array Analysis
Neoplasm Staging
Staining and Labeling
Estrogen Receptors
Multivariate Analysis
Survival Rate
Lymph Nodes
Survival
Neoplasms

Keywords

  • Breast cancer
  • FACL4
  • Tissue microarrays

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Tsai, C. H., Sheen-Chen, S. M., Huang, C. Y., Chen, Y. J., Chi, S. Y., Ko, S. F., ... Tang, R. P. (2014). An evaluation of fatty acid-CoA ligase 4 in breast cancer. Anticancer Research, 34(3), 1239-1243.

An evaluation of fatty acid-CoA ligase 4 in breast cancer. / Tsai, Chin Hua; Sheen-Chen, Shyr Ming; Huang, Chun Ying; Chen, Ying Ju; Chi, Shun Yu; Ko, Sheung Fat; Lee, Yi Wei; Liang, Jiun Lung; Hsu, Hsien Wen; Huang, Eng Yen; Chen, Hui Chun; Huang, Chao Cheng; Rau, Kung Ming; Tang, Rei Ping.

In: Anticancer Research, Vol. 34, No. 3, 01.03.2014, p. 1239-1243.

Research output: Contribution to journalArticle

Tsai, CH, Sheen-Chen, SM, Huang, CY, Chen, YJ, Chi, SY, Ko, SF, Lee, YW, Liang, JL, Hsu, HW, Huang, EY, Chen, HC, Huang, CC, Rau, KM & Tang, RP 2014, 'An evaluation of fatty acid-CoA ligase 4 in breast cancer', Anticancer Research, vol. 34, no. 3, pp. 1239-1243.
Tsai CH, Sheen-Chen SM, Huang CY, Chen YJ, Chi SY, Ko SF et al. An evaluation of fatty acid-CoA ligase 4 in breast cancer. Anticancer Research. 2014 Mar 1;34(3):1239-1243.
Tsai, Chin Hua ; Sheen-Chen, Shyr Ming ; Huang, Chun Ying ; Chen, Ying Ju ; Chi, Shun Yu ; Ko, Sheung Fat ; Lee, Yi Wei ; Liang, Jiun Lung ; Hsu, Hsien Wen ; Huang, Eng Yen ; Chen, Hui Chun ; Huang, Chao Cheng ; Rau, Kung Ming ; Tang, Rei Ping. / An evaluation of fatty acid-CoA ligase 4 in breast cancer. In: Anticancer Research. 2014 ; Vol. 34, No. 3. pp. 1239-1243.
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