Abstract
Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p
| Original language | English |
|---|---|
| Pages (from-to) | 387-393 |
| Number of pages | 7 |
| Journal | International Journal of Cancer |
| Volume | 124 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 15 2009 |
| Externally published | Yes |
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Keywords
- Cpg islands
- Epigenetics
- Methylation-specific pcr
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
An epigenetic marker panel for screening and prognostic prediction of ovarian cancer. / Su, Her Young; Lai, Hung Cheng; Lin, Ya Wen; Chou, Yu Ching; Liu, Chin Yu; Yu, Mu Hsien.
In: International Journal of Cancer, Vol. 124, No. 2, 15.01.2009, p. 387-393.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An epigenetic marker panel for screening and prognostic prediction of ovarian cancer
AU - Su, Her Young
AU - Lai, Hung Cheng
AU - Lin, Ya Wen
AU - Chou, Yu Ching
AU - Liu, Chin Yu
AU - Yu, Mu Hsien
PY - 2009/1/15
Y1 - 2009/1/15
N2 - Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p
AB - Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p
KW - Cpg islands
KW - Epigenetics
KW - Methylation-specific pcr
KW - Ovarian cancer
UR - http://www.scopus.com/inward/record.url?scp=58249087346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58249087346&partnerID=8YFLogxK
U2 - 10.1002/ijc.23957
DO - 10.1002/ijc.23957
M3 - Article
C2 - 18942711
AN - SCOPUS:58249087346
VL - 124
SP - 387
EP - 393
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -