An epigenetic marker panel for screening and prognostic prediction of ovarian cancer

Her Young Su; Hung Cheng Lai; Ya Wen Lin; Yu Ching Chou; Chin Yu Liu; Mu Hsien Yu

doi:10.1002/ijc.23957

An epigenetic marker panel for screening and prognostic prediction of ovarian cancer

Her Young Su, Hung Cheng Lai, Ya Wen Lin, Yu Ching Chou, Chin Yu Liu, Mu Hsien Yu

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p

Original language	English
Pages (from-to)	387-393
Number of pages	7
Journal	International Journal of Cancer
Volume	124
Issue number	2
DOIs	https://doi.org/10.1002/ijc.23957
Publication status	Published - Jan 15 2009
Externally published	Yes

Keywords

Cpg islands
Epigenetics
Methylation-specific pcr
Ovarian cancer

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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AU - Lai, Hung Cheng

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AU - Chou, Yu Ching

AU - Liu, Chin Yu

AU - Yu, Mu Hsien

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