Abstract
Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p
Original language | English |
---|---|
Pages (from-to) | 387-393 |
Number of pages | 7 |
Journal | International Journal of Cancer |
Volume | 124 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jan 15 2009 |
Externally published | Yes |
Keywords
- Cpg islands
- Epigenetics
- Methylation-specific pcr
- Ovarian cancer
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)