An epigenetic marker panel for screening and prognostic prediction of ovarian cancer

Her Young Su, Hung Cheng Lai, Ya Wen Lin, Yu Ching Chou, Chin Yu Liu, Mu Hsien Yu

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

Aberrant CpG island hypermethylation is a common finding of cancers, which might be detectable in the tissue or serum of affected patients. We analyzed DNA methylation by methylation-specific polymerase chain reaction of 7 genes, which included secreted frizzled receptor proteins 1, 2, 4, 5 (SFRPI, 2, 4, 5), SRY-box 1 (SOX1), paired box gene 1 (PAX1) and LIM homeobox transcription factor 1, alpha (LMX1A) in primary tumor samples from 126 patients with ovarian cancer, 75 with a benign tumor and 14 with borderline malignancy of an ovarian tumor, and in the serum from 26 patients with ovarian cancer and 20 with a benign tumor. Six of 7 genes had higher methylation rates in patients with ovarian cancer than in borderline malignancy or benign tumor (p

Original languageEnglish
Pages (from-to)387-393
Number of pages7
JournalInternational Journal of Cancer
Volume124
Issue number2
DOIs
Publication statusPublished - Jan 15 2009
Externally publishedYes

Keywords

  • Cpg islands
  • Epigenetics
  • Methylation-specific pcr
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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