An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan

Hsi Hsun Lin, Yi Li Shih, Yung Ching Liu, Susan Shin Jung Lee, Chun Kai Huang, Ya Lei Chen, Chuen Chin, Chung Hsu Lai, Hung Chin Tsai, Yi Chi Guo, Linqi Zhang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The human immunodeficiency virus type 1 (HIV-1) epidemic in Taiwan is rapidly escalating because of an increasing number of injection drug users (IDUs). A molecular epidemiological study of HIV-1-infected IDUs in Taiwan was conducted from January 2004 to April 2005. Of the 131 HIV-1-positive specimens collected, all contained detectable sequences, including 105 from the C2-V3 region of env and 87 from the protease and reverse transcriptase genes of pol. Phylogenetic analysis of these sequences indicated that 128 individuals harbored CRF07_BC, which resembles the dominant strains circulating among IDUs in China. Twenty-three individuals had a history of travel to the southwest provinces of China and shared needles or apparatuses there. This suggests that CRF07_BC might have been transmitted from China into Taiwan, thereby causing an outbreak among IDUs in Taiwan. This is the first report in the English literature of the appearance of HIV-1 CRF07_BC in Taiwan. These provide information relevant to the development of antiviral therapy and vaccine in Taiwan and may assist public health workers in the prevention of HIV-1 spread.

Original languageEnglish
Pages (from-to)248-255
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume42
Issue number2
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Fingerprint

Drug Users
Taiwan
HIV-1
Injections
Infection
China
pol Genes
Literature
Active Immunotherapy
RNA-Directed DNA Polymerase
Needles
Antiviral Agents
Disease Outbreaks
Sequence Analysis
Epidemiologic Studies
Peptide Hydrolases
Public Health

Keywords

  • CRF07_BC
  • HIV-1
  • Injection drug user
  • Taiwan

ASJC Scopus subject areas

  • Virology
  • Immunology

Cite this

An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan. / Lin, Hsi Hsun; Shih, Yi Li; Liu, Yung Ching; Lee, Susan Shin Jung; Huang, Chun Kai; Chen, Ya Lei; Chin, Chuen; Lai, Chung Hsu; Tsai, Hung Chin; Guo, Yi Chi; Zhang, Linqi.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 42, No. 2, 06.2006, p. 248-255.

Research output: Contribution to journalArticle

Lin, HH, Shih, YL, Liu, YC, Lee, SSJ, Huang, CK, Chen, YL, Chin, C, Lai, CH, Tsai, HC, Guo, YC & Zhang, L 2006, 'An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan', Journal of Acquired Immune Deficiency Syndromes, vol. 42, no. 2, pp. 248-255. https://doi.org/10.1097/01.qai.0000214818.80539.da
Lin, Hsi Hsun ; Shih, Yi Li ; Liu, Yung Ching ; Lee, Susan Shin Jung ; Huang, Chun Kai ; Chen, Ya Lei ; Chin, Chuen ; Lai, Chung Hsu ; Tsai, Hung Chin ; Guo, Yi Chi ; Zhang, Linqi. / An epidemic of HIV type I CRF07_BC infection among injection drug users in Taiwan. In: Journal of Acquired Immune Deficiency Syndromes. 2006 ; Vol. 42, No. 2. pp. 248-255.
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