An amphiphilic silicone-modified polysaccharide molecular hybrid with in situ forming of hierarchical superporous architecture upon swelling

Wei Chen Huang, San Yuan Chen, Dean Mo Liu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Most hydrogels face the challenge that extensive water uptake deteriorates their mechanical integrity, which restricts potential uses and, in some cases, reduces therapeutic performance in biomedical applications. Motivated by the concept that structural optimization was able to improve the mechanical properties whilst maintaining a high water uptake, in this work we designed a new type of strong network, i.e. PDMS-crosslinked-NOCC polymer networks (PMSC CAPNs), by esterification between cross-linked PDMS diol (bis(hydroxyalkyl) terminated polydimethylsiloxane, silicone) and NOCC (N,O-carboxymethyl chitosan). By manipulating the cross-linked density with PDMS, a hierarchical structure in which PDMS-rich microgels were randomly distributed within the underlying PMSC hydrogel could be tailored through the control of polymer-polymer and polymer-solvent interactions. Besides, the resulting hybrid hydrogel displayed an efficient self-foaming capability to create in situ a hierarchical superporous microarchitecture upon swelling. The swelling behavior accounted for by Flory-Rehner theory indicated that the PDMS macromonomeric crosslinker not only caused the development of a superporous microarchitecture under solvation effects but also escalated both strength and elasticity to the final hydrogel. A new swelling model based on spectroscopic examination of the PMSC CAPNs was successfully proposed, which nicely defined the unique structural transition of the hydrogel upon swelling. We also envision the potential development of such a hybrid hydrogel for advanced biomedical applications.

Original languageEnglish
Pages (from-to)10868-10876
Number of pages9
JournalSoft Matter
Volume8
Issue number42
DOIs
Publication statusPublished - Nov 14 2012
Externally publishedYes

Fingerprint

polysaccharides
Hydrogel
silicones
Silicones
swelling
Polysaccharides
Swelling
Polymers
polymers
foaming
Hydrogels
integrity
Water
Structural optimization
water
solvation
Solvation
Esterification
elastic properties
examination

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

An amphiphilic silicone-modified polysaccharide molecular hybrid with in situ forming of hierarchical superporous architecture upon swelling. / Huang, Wei Chen; Chen, San Yuan; Liu, Dean Mo.

In: Soft Matter, Vol. 8, No. 42, 14.11.2012, p. 10868-10876.

Research output: Contribution to journalArticle

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