Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

N. Shahrizaila, G. Sobue, S. Kuwabara, S. H. Kim, Carol Birks, D. S. Fan, J. S. Bae, C. J. Hu, M. Gourie-Devi, Y. Noto, K. Shibuya, K. J. Goh, R. Kaji, C. P. Tsai, L. Cui, P. Talman, R. D. Henderson, S. Vucic, M. C. Kiernan

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30 Citations (Scopus)

Abstract

While the past 2 decades have witnessed an increasing understanding of amyotrophic lateral sclerosis (ALS) arising from East Asia, particularly Japan, South Korea, Taiwan and China, knowledge of ALS throughout the whole of Asia remains limited. Asia represents >50% of the world population, making it host to the largest patient cohort of ALS. Furthermore, Asia represents a diverse population in terms of ethnic, social and cultural backgrounds. In this review, an overview is presented that covers what is currently known of ALS in Asia from basic epidemiology and genetic influences, through to disease characteristics including atypical phenotypes which manifest a predilection for Asians. With the recent establishment of the Pan-Asian Consortium for Treatment and Research in ALS to facilitate collaborations between clinicians and researchers across the region, it is anticipated that Asia and the Pacific will contribute to unravelling the uncertainties in ALS.

Original languageEnglish
Pages (from-to)821-830
Number of pages10
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume87
Issue number8
DOIs
Publication statusPublished - Jan 8 2016

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Keywords

  • ALS
  • EPIDEMIOLOGY
  • MOTOR NEURON DISEASE

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)
  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Shahrizaila, N., Sobue, G., Kuwabara, S., Kim, S. H., Birks, C., Fan, D. S., Bae, J. S., Hu, C. J., Gourie-Devi, M., Noto, Y., Shibuya, K., Goh, K. J., Kaji, R., Tsai, C. P., Cui, L., Talman, P., Henderson, R. D., Vucic, S., & Kiernan, M. C. (2016). Amyotrophic lateral sclerosis and motor neuron syndromes in Asia. Journal of Neurology, Neurosurgery and Psychiatry, 87(8), 821-830. https://doi.org/10.1136/jnnp-2015-312751