Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study

Chieh Mo Lin, Shu Min Lin, Fu Tsai Chung, Horng Chyuan Lin, Kang Yun Lee, Chien Da Huang, Chih Hsi Kuo, Chien Ying Liu, Chun Hua Wang, Han Pin Kuo

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Abstract

Background: The study was designed to investigate the clinical usefulness of Amplified Mycobacterium Tuberculosis Direct (AMTD) tests for diagnosing TB pleurisy.

Methods: One hundred and fifty-two patients for whom the exclusion of tuberculous pleural effusion was necessary were retrospectively analyzed.

Results: The sensitivity of AMTD in diagnosing pleural TB was 36.4% (20 of 55). Combining sputum and pleural effusion AFB smear, pleural biopsy, and AMTD test of pleural effusion increased sensitivity to 82.5% (33/40). There were significantly higher percentages of neutrophils in the pleural effusion in the positive than in the negative AMTD group (38.0 ± 6.7% vs. 11.1 ± 3.7%, p18 days (70% vs. 31.4%; OR 5.09; 95% CI 1.54-16.79; p = 0.011).

Conclusions: Combining AMTD tests with conventional diagnostic methods offer good sensitivity for pleural TB diagnosis. Patients in the early course of the disease are better candidates for AMTD tests.

Original languageEnglish
Article numbere44842
JournalPLoS One
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 10 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lin, C. M., Lin, S. M., Chung, F. T., Lin, H. C., Lee, K. Y., Huang, C. D., Kuo, C. H., Liu, C. Y., Wang, C. H., & Kuo, H. P. (2012). Amplified mycobacterium tuberculosis direct test for diagnosing tuberculous pleurisy-a diagnostic accuracy study. PLoS One, 7(9), [e44842]. https://doi.org/10.1371/journal.pone.0044842