Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma

Ju Fang Liu, Ya Ting Tsao, Chun Han Hou

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Osteosarcoma is a common, high malignant, and metastatic bone cancer. Amphiregulin (AREG) has been associated with cancer cellular activities. However, the effect of AREG on metastasis activity in human osteosarcoma cells has yet to be determined. We determined that AREG increases the expression of intercellular adhesion molecule-1 (ICAM-1) through PI3K/Akt signaling pathway via its interaction with the epidermal growth factor receptor, thus resulting in the enhanced cell migration of osteosarcoma. Furthermore, AREG stimulation increased the association of NF-κB to ICAM-1 promoter which then up-regulated ICAM-1 expression. Finally, we observed that shRNA silencing of AREG decreased osteosarcoma metastasis in vivo. Our findings revealed a relationship between osteosarcoma metastatic potential and AREG expression and the modulating effect of AREG on ICAM-1 expression.

Original languageEnglish
Pages (from-to)40880-40895
Number of pages16
JournalOncotarget
Volume6
Issue number38
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Amphiregulin
  • Cell migration
  • EGFR
  • ICAM-1
  • Osteosarcoma metastasis

ASJC Scopus subject areas

  • Oncology

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