Ameliorative effects of stabilized rice bran on type 2 diabetes patients

Hsing Hsien Cheng, Hsin Yi Huang, Ya Yen Chen, Chen Ling Huang, Chun Jen Chang, Hsiao Lien Chen, Ming Hoang Lai

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background/Aim: While it has been demonstrated that rice bran might lower the cholesterol level in hypercholesterolemic individuals, its effects on the levels of adiponectin and glycated hemoglobin (HbA1c) in patients with type 2 diabetes mellitus remain unknown. Methods: Twenty-eight volunteers with type 2 diabetes were randomly divided into 2 groups, one of which received a dietary supplement of 20 g of stabilized rice bran and the other placebo once daily for 12 weeks. Parameters such as the level of HbA1c, glucose, insulin, homeostasis model assessment for estimation of relative insulin resistance, high-density and low-density lipoprotein (LDL) cholesterol and adiponectin were evaluated. Results: At the end of the study period, postprandial glucose and the area under the glucose curve of the rice bran group were significantly lower than baseline levels by 14.4 and 15.7%, respectively. Compared to baseline, the HbA1c values in the rice bran group were also significantly lower. Serum total cholesterol and LDL cholesterol concentrations in the rice bran group were 9.2 and 13.7% lower, respectively, than in the placebo group. The plasma free fatty acid and adiponectin concentrations were 20% lower and 40% higher in the rice bran group compared to the placebo group. Conclusions: This study demonstrated that stabilized rice bran can lower the level of HbA1c and blood lipids and increase blood adiponectin concentrations in type 2 diabetic subjects. In light of this, we conclude that stabilized rice bran may represent an important functional nutrient to ameliorate lipid and glycemic anomalies in type 2 diabetic subjects.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalAnnals of Nutrition and Metabolism
Volume56
Issue number1
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Type 2 Diabetes Mellitus
Adiponectin
Placebos
Glucose
LDL Cholesterol
Cholesterol
Postprandial Period
Lipids
Oryza
Glycosylated Hemoglobin A
Dietary Supplements
Nonesterified Fatty Acids
Area Under Curve
Insulin Resistance
Volunteers
Homeostasis
Insulin
Food
Serum

Keywords

  • Adiponectin
  • Fatty acid
  • Glycated hemoglobin
  • Placebo
  • Rice bran
  • Type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Cheng, H. H., Huang, H. Y., Chen, Y. Y., Huang, C. L., Chang, C. J., Chen, H. L., & Lai, M. H. (2010). Ameliorative effects of stabilized rice bran on type 2 diabetes patients. Annals of Nutrition and Metabolism, 56(1), 45-51. https://doi.org/10.1159/000265850

Ameliorative effects of stabilized rice bran on type 2 diabetes patients. / Cheng, Hsing Hsien; Huang, Hsin Yi; Chen, Ya Yen; Huang, Chen Ling; Chang, Chun Jen; Chen, Hsiao Lien; Lai, Ming Hoang.

In: Annals of Nutrition and Metabolism, Vol. 56, No. 1, 02.2010, p. 45-51.

Research output: Contribution to journalArticle

Cheng, HH, Huang, HY, Chen, YY, Huang, CL, Chang, CJ, Chen, HL & Lai, MH 2010, 'Ameliorative effects of stabilized rice bran on type 2 diabetes patients', Annals of Nutrition and Metabolism, vol. 56, no. 1, pp. 45-51. https://doi.org/10.1159/000265850
Cheng, Hsing Hsien ; Huang, Hsin Yi ; Chen, Ya Yen ; Huang, Chen Ling ; Chang, Chun Jen ; Chen, Hsiao Lien ; Lai, Ming Hoang. / Ameliorative effects of stabilized rice bran on type 2 diabetes patients. In: Annals of Nutrition and Metabolism. 2010 ; Vol. 56, No. 1. pp. 45-51.
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