Ambient air pollution and risk of tuberculosis

A cohort study

Ting Chun Lai, Chen Yuan Chiang, Chang Fu Wu, Shiang Lin Yang, Ding Ping Liu, Chang Chuan Chan, Hsien Ho Lin

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objectives: Several respirable hazards, including smoking and indoor air pollution from biomass, were suggested to increase the risk of tuberculosis. Few studies have been conducted on ambient air pollution and tuberculosis. We investigated the association between exposure to ambient air pollution and incidence of active tuberculosis. Methods: We conducted a cohort study using 106 678 participants of a community-based screening service in Taiwan, 2005-2012. We estimated individual exposure to air pollution using data from the nearest air quality monitoring station and the road intensity within a 500 m buffer zone. The incidence of tuberculosis was ascertained from the national tuberculosis registry. Results: After a median follow-up of 6.7 years, 418 cases of tuberculosis occurred. Exposure to fine particulate matter (PM2.5) was associated with increased risk of active tuberculosis (adjusted HR: 1.39/10 μg/m3 (95% CI 0.95 to 2.03)). In addition, traffic-related air pollution including nitrogen dioxide (adjusted HR: 1.33/10 ppb; 95% CI 1.04 to 1.70), nitrogen oxides (adjusted HR: 1.21/10 ppb; 95% CI 1.04 to 1.41) and carbon monoxide (adjusted HR: 1.89/ppm; 95% CI 0.78 to 4.58) was associated with tuberculosis risk. There was a non-significant trend between the length of major roads in the neighbourhood and culture-confirmed tuberculosis (adjusted HR: 1.04/km; 95% CI 0.995 to 1.09). Conclusions: Our study revealed a possible link between ambient air pollution and risk of active tuberculosis. Since people from developing countries continue to be exposed to high levels of ambient air pollution and to experience high rates of tuberculosis, the impact of worsening air pollution on global tuberculosis control warrants further investigation.

Original languageEnglish
Pages (from-to)56-61
Number of pages6
JournalOccupational and Environmental Medicine
Volume73
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Air Pollution
Tuberculosis
Cohort Studies
Nitrogen Oxides
Indoor Air Pollution
Nitrogen Dioxide
Particulate Matter
Incidence
Carbon Monoxide
Taiwan
Biomass
Developing Countries
Registries
Buffers
Smoking
Air

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Ambient air pollution and risk of tuberculosis : A cohort study. / Lai, Ting Chun; Chiang, Chen Yuan; Wu, Chang Fu; Yang, Shiang Lin; Liu, Ding Ping; Chan, Chang Chuan; Lin, Hsien Ho.

In: Occupational and Environmental Medicine, Vol. 73, No. 1, 01.01.2016, p. 56-61.

Research output: Contribution to journalArticle

Lai, Ting Chun ; Chiang, Chen Yuan ; Wu, Chang Fu ; Yang, Shiang Lin ; Liu, Ding Ping ; Chan, Chang Chuan ; Lin, Hsien Ho. / Ambient air pollution and risk of tuberculosis : A cohort study. In: Occupational and Environmental Medicine. 2016 ; Vol. 73, No. 1. pp. 56-61.
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abstract = "Objectives: Several respirable hazards, including smoking and indoor air pollution from biomass, were suggested to increase the risk of tuberculosis. Few studies have been conducted on ambient air pollution and tuberculosis. We investigated the association between exposure to ambient air pollution and incidence of active tuberculosis. Methods: We conducted a cohort study using 106 678 participants of a community-based screening service in Taiwan, 2005-2012. We estimated individual exposure to air pollution using data from the nearest air quality monitoring station and the road intensity within a 500 m buffer zone. The incidence of tuberculosis was ascertained from the national tuberculosis registry. Results: After a median follow-up of 6.7 years, 418 cases of tuberculosis occurred. Exposure to fine particulate matter (PM2.5) was associated with increased risk of active tuberculosis (adjusted HR: 1.39/10 μg/m3 (95{\%} CI 0.95 to 2.03)). In addition, traffic-related air pollution including nitrogen dioxide (adjusted HR: 1.33/10 ppb; 95{\%} CI 1.04 to 1.70), nitrogen oxides (adjusted HR: 1.21/10 ppb; 95{\%} CI 1.04 to 1.41) and carbon monoxide (adjusted HR: 1.89/ppm; 95{\%} CI 0.78 to 4.58) was associated with tuberculosis risk. There was a non-significant trend between the length of major roads in the neighbourhood and culture-confirmed tuberculosis (adjusted HR: 1.04/km; 95{\%} CI 0.995 to 1.09). Conclusions: Our study revealed a possible link between ambient air pollution and risk of active tuberculosis. Since people from developing countries continue to be exposed to high levels of ambient air pollution and to experience high rates of tuberculosis, the impact of worsening air pollution on global tuberculosis control warrants further investigation.",
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