Altitude hypoxia increases glucose uptake in human heart

Chi Hsien Chen, Yuh Feng Liu, Shin Da Lee, Chih Yang Huang, Wen Chih Lee, Ying Lan Tsai, Chien Wen Hou, Yi Sheng Chan, Chia Hua Kuo

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cardiac muscle is a highly oxygenated tissue that produces ATP mainly from fat oxidation. However, when the rate of oxygen demand exceeds oxygen supply, energy reliance on the carbohydrate substrate becomes crucial for sustaining normal cardiac function. In this study, the effect of acute altitude hypoxia on glucose uptake from circulation was determined, for the first time, in the human heart, using [18F]-2-deoxy-2-fluoro-D-glucose positron emission tomography (FDG-PET) in a simulated altitude condition (14% O2, corresponding to ∼3000 m above sea level) or room air (21% O2). Our results showed that subjects (n = 6) started to experience difficulty in sustaining the hypoxic condition at ∼45 min. This was concurrent with a substantially increased blood lactate concentration, which reflects an accelerated rate of anaerobic glycolysis. Hypoxia elevated FDG uptake above control by ∼70% in heart, but not in limbs (representing primarily skeletal muscle), brain, and liver. This study provides the first human evidence for the hypoxia-stimulated glucose uptake in heart. At this hypoxia level, the previously observed hypoxia-stimulated glucose uptake in rat skeletal muscle was not confirmed in the human study.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalHigh Altitude Medicine and Biology
Volume10
Issue number1
DOIs
Publication statusPublished - Mar 1 2009

Fingerprint

Altitude Sickness
Glucose
Skeletal Muscle
Oxygen
Fluorodeoxyglucose F18
Glycolysis
Oceans and Seas
Positron-Emission Tomography
Lactic Acid
Myocardium
Extremities
Adenosine Triphosphate
Fats
Air
Carbohydrates
Hypoxia
Liver
Brain

Keywords

  • Altitude
  • Cardiac muscle
  • Glucose transport
  • Myocardium

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Public Health, Environmental and Occupational Health

Cite this

Chen, C. H., Liu, Y. F., Lee, S. D., Huang, C. Y., Lee, W. C., Tsai, Y. L., ... Kuo, C. H. (2009). Altitude hypoxia increases glucose uptake in human heart. High Altitude Medicine and Biology, 10(1), 83-86. https://doi.org/10.1089/ham.2008.1064

Altitude hypoxia increases glucose uptake in human heart. / Chen, Chi Hsien; Liu, Yuh Feng; Lee, Shin Da; Huang, Chih Yang; Lee, Wen Chih; Tsai, Ying Lan; Hou, Chien Wen; Chan, Yi Sheng; Kuo, Chia Hua.

In: High Altitude Medicine and Biology, Vol. 10, No. 1, 01.03.2009, p. 83-86.

Research output: Contribution to journalArticle

Chen, CH, Liu, YF, Lee, SD, Huang, CY, Lee, WC, Tsai, YL, Hou, CW, Chan, YS & Kuo, CH 2009, 'Altitude hypoxia increases glucose uptake in human heart', High Altitude Medicine and Biology, vol. 10, no. 1, pp. 83-86. https://doi.org/10.1089/ham.2008.1064
Chen CH, Liu YF, Lee SD, Huang CY, Lee WC, Tsai YL et al. Altitude hypoxia increases glucose uptake in human heart. High Altitude Medicine and Biology. 2009 Mar 1;10(1):83-86. https://doi.org/10.1089/ham.2008.1064
Chen, Chi Hsien ; Liu, Yuh Feng ; Lee, Shin Da ; Huang, Chih Yang ; Lee, Wen Chih ; Tsai, Ying Lan ; Hou, Chien Wen ; Chan, Yi Sheng ; Kuo, Chia Hua. / Altitude hypoxia increases glucose uptake in human heart. In: High Altitude Medicine and Biology. 2009 ; Vol. 10, No. 1. pp. 83-86.
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