Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/hyperactivity disorder

Huey Ling Chiang, Yu Jen Chen, Yu Chun Lo, Wen Yih Isaac Tseng, Susan Shur Fen Gau

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: The neural substrate for clinical symptoms and neuropsychological performance in individuals with attention-deficit/hyperactivity disorder (ADHD) has rarely been studied and has yielded inconsistent results. We sought to compare the microstructural property of fibre tracts associated with the prefrontal cortex and its association with ADHD symptoms and a wide range of attention performance in youth with ADHD and healthy controls. Methods: We assessed youths with ADHD and age-, sex-, handedness-, coil- and intelligence-matched controls using the Conners’ Continuous Performance Test (CCPT) for attention performance and MRI. The 10 target tracts, including the bilateral frontostriatal tracts (caudate to dorsolateral prefrontal cortex, ventrolateral prefrontal cortex and orbitofrontal cortex), superior longitudinal fasciculus (SLF) and cingulum bundle were reconstructed using diffusion spectrum imaging tractography. We computed generalized fractional anisotropy (GFA) values to indicate tract-specific microstructural property. Results: We included 50 youths with ADHD and 50 healthy controls in our study. Youths with ADHD had lower GFA in the left frontostriatal tracts, bilateral SLF and right cingulum bundle and performed worse in the CCPT than controls. Furthermore, alteration of the right SLF GFA was most significantly associated with the clinical symptom of inattention in youths with ADHD. Finally, youths with ADHD had differential association patterns of the 10 fibre tract GFA values with attention performance compared with controls. Limitations: Ten of the youths with ADHD were treated with methylphenidate, which may have long-term effects on microstructural property. Conclusion: Our study highlights the importance of the SLF, cingulum bundle and frontostriatal tracts for clinical symptoms and attention performance in youths with ADHD and demonstrates the involvement of different fibre tracts in attention performance in these individuals.

Original languageEnglish
Pages (from-to)325-335
Number of pages11
JournalJournal of Psychiatry and Neuroscience
Volume40
Issue number5
DOIs
Publication statusPublished - Sep 1 2015
Externally publishedYes

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Impulsive Behavior
Attention Deficit Disorder with Hyperactivity
Anisotropy
Prefrontal Cortex
White Matter
Functional Laterality
Methylphenidate
Intelligence

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Pharmacology (medical)

Cite this

Altered white matter tract property related to impaired focused attention, sustained attention, cognitive impulsivity and vigilance in attention-deficit/hyperactivity disorder. / Chiang, Huey Ling; Chen, Yu Jen; Lo, Yu Chun; Tseng, Wen Yih Isaac; Gau, Susan Shur Fen.

In: Journal of Psychiatry and Neuroscience, Vol. 40, No. 5, 01.09.2015, p. 325-335.

Research output: Contribution to journalArticle

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