Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects

Simone Grimm, Peter Boesiger, Johannes Beck, Daniel Schuepbach, Felix Bermpohl, Martin Walter, Jutta Ernst, Daniel Hell, Heinz Boeker, Georg Northoff

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

Studies using functional magnetic resonance imaging (fMRI) show predominant negative blood oxygenation level-dependent (BOLD) responses (NBRs) in regions of the default-mode network such as the pregenual anterior cingulate cortex, the ventromedial prefrontal cortex, and the posterior cingulate cortex. Patients with major depressive disorder (MDD) show emotional-cognitive disturbances, which have been associated with alterations within the default-mode network. However, it remains unclear whether these default-mode network alterations are related to abnormalities in NBRs. We therefore investigated neural activity in the default-mode network during different emotional tasks in patients with MDD in an event-related fMRI design. MDD patients showed significantly reduced NBRs in several regions of the default-mode network. Decreased NBRs in MDD patients correlated with depression severity and feelings of hopelessness. In sum, our findings demonstrate that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.

Original languageEnglish
Pages (from-to)932-943
Number of pages12
JournalNeuropsychopharmacology
Volume34
Issue number4
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Major Depressive Disorder
Emotions
Gyrus Cinguli
Magnetic Resonance Imaging
Affective Symptoms
Prefrontal Cortex
Depression

Keywords

  • Default-mode network
  • Emotional processing
  • Event-related fMRI
  • Major depressive disorder
  • Negative BOLD responses

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. / Grimm, Simone; Boesiger, Peter; Beck, Johannes; Schuepbach, Daniel; Bermpohl, Felix; Walter, Martin; Ernst, Jutta; Hell, Daniel; Boeker, Heinz; Northoff, Georg.

In: Neuropsychopharmacology, Vol. 34, No. 4, 03.2009, p. 932-943.

Research output: Contribution to journalArticle

Grimm, S, Boesiger, P, Beck, J, Schuepbach, D, Bermpohl, F, Walter, M, Ernst, J, Hell, D, Boeker, H & Northoff, G 2009, 'Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects', Neuropsychopharmacology, vol. 34, no. 4, pp. 932-943. https://doi.org/10.1038/npp.2008.81
Grimm, Simone ; Boesiger, Peter ; Beck, Johannes ; Schuepbach, Daniel ; Bermpohl, Felix ; Walter, Martin ; Ernst, Jutta ; Hell, Daniel ; Boeker, Heinz ; Northoff, Georg. / Altered negative BOLD responses in the default-mode network during emotion processing in depressed subjects. In: Neuropsychopharmacology. 2009 ; Vol. 34, No. 4. pp. 932-943.
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