Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats

Sean Tanabe, Zirui Huang, Jun Zhang, Yali Chen, Stuart Fogel, Julien Doyon, Jinsong Wu, Jianghui Xu, Jianfeng Zhang, Pengmin Qin, Xuehai Wu, Ying Mao, George A. Mashour, Anthony G. Hudetz, Georg Northoff

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Consciousness is supported by integrated brain activity across widespread functionally segregated networks. The functional magnetic resonance imaging-derived global brain signal is a candidate marker for a conscious state, and thus the authors hypothesized that unconsciousness would be accompanied by a loss of global temporal coordination, with specific patterns of decoupling between local regions and global activity differentiating among various unconscious states. Methods: Functional magnetic resonance imaging global signals were studied in physiologic, pharmacologic, and pathologic states of unconsciousness in human natural sleep (n = 9), propofol anesthesia (humans, n = 14; male rats, n = 12), and neuropathological patients (n = 21). The global signal amplitude as well as the correlation between global signal and signals of local voxels were quantified. The former reflects the net strength of global temporal coordination, and the latter yields global signal topography. Results: A profound reduction of global signal amplitude was seen consistently across the various unconscious states: Wakefulness (median [1st, 3rd quartile], 0.46 [0.21, 0.50]) versus non-rapid eye movement stage 3 of sleep (0.30 [0.24, 0.32]; P = 0.035), wakefulness (0.36 [0.31, 0.42]) versus general anesthesia (0.25 [0.21, 0.28]; P = 0.001), healthy controls (0.30 [0.27, 0.37]) versus unresponsive wakefulness syndrome (0.22 [0.15, 0.24]; P < 0.001), and low dose (0.07 [0.06, 0.08]) versus high dose of propofol (0.04 [0.03, 0.05]; P = 0.028) in rats. Furthermore, non-rapid eye movement stage 3 of sleep was characterized by a decoupling of sensory and attention networks from the global network. General anesthesia and unresponsive wakefulness syndrome were characterized by a dissociation of the majority of functional networks from the global network. This decoupling, however, was dominated by distinct neuroanatomic foci (e.g., precuneus and anterior cingulate cortices). Conclusions: The global temporal coordination of various modules across the brain may distinguish the coarse-grained state of consciousness versus unconsciousness, while the relationship between the global and local signals may define the particular qualities of a particular unconscious state.

Original languageEnglish
Pages (from-to)1392-1406
Number of pages15
JournalAnesthesiology
Volume132
Issue number6
DOIs
Publication statusPublished - Jun 2020

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats'. Together they form a unique fingerprint.

  • Cite this

    Tanabe, S., Huang, Z., Zhang, J., Chen, Y., Fogel, S., Doyon, J., Wu, J., Xu, J., Zhang, J., Qin, P., Wu, X., Mao, Y., Mashour, G. A., Hudetz, A. G., & Northoff, G. (2020). Altered Global Brain Signal during Physiologic, Pharmacologic, and Pathologic States of Unconsciousness in Humans and Rats. Anesthesiology, 132(6), 1392-1406. https://doi.org/10.1097/ALN.0000000000003197