Altered frequency characteristic of central vasomotor control in SHR

Terry B J Kuo, Cheryl C H Yang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Previous work from our laboratory has demonstrated that the very low- frequency (VLF: 0-0.25 Hz) and low-frequency (LF: 0.25-0.8 Hz) power of arterial pressure variability (APV) are related to vasomotor reactivity in response to control signals from the rostral ventrolateral medulla (RVLM) via the sympathetic system in the rat. The present study evaluated the differences in the dynamic property of central vasomotor control between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). Experiments were carried out in 10- to 12-wk-old rats that were anesthetized with continuous infusion of pentobarbital sodium, paralyzed with pancuronium, and maintained on mechanical ventilation. We found that SHR exhibited significantly higher arterial pressure (AP), heart rate (HR), and VLF, LF, and high-frequency (0.8-2.4 Hz) power of APV than WKY under resting state. Broad-band electrical stimulation of the RVLM elicited parallel APV in the VLF and LF ranges in both rat strains. The evoked APV and transfer magnitude of the APV to stimulus spike rate variability (RVLM-AP magnitude) were significantly higher in SHR, especially in the LF range. The response frequency of central vasomotor control, represented by the high-cut frequency of RVLM-AP magnitude, was also extended in SHR. The disparity in RVLM-AP transfer magnitude between SHR and WKY became virtually absent after combined α- and β-adrenoceptor blockade by phentolamine and propranolol. These results suggest that the dynamic control of RVLM on AP reactivity is enhanced in SHR, in which the adrenergic system may play a major role.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume278
Issue number1 47-1
Publication statusPublished - Jan 2000
Externally publishedYes

Fingerprint

Inbred SHR Rats
Arterial Pressure
Inbred WKY Rats
Pancuronium
Phentolamine
Pentobarbital
Artificial Respiration
Propranolol
Adrenergic Agents
Adrenergic Receptors
Electric Stimulation
Heart Rate

Keywords

  • Arterial pressure variability
  • Broad-band stimulation
  • Coherence
  • Rostral ventrolateral medulla
  • Transfer function

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Altered frequency characteristic of central vasomotor control in SHR. / Kuo, Terry B J; Yang, Cheryl C H.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 278, No. 1 47-1, 01.2000.

Research output: Contribution to journalArticle

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