Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder

Chia Wei Lin, Hsiang Yuan Lin, Yu Chun Lo, Yu Jen Chen, Yung Chin Hsu, Yi Lung Chen, Wen Yih Isaac Tseng, Susan Shur Fen Gau

Research output: Contribution to journalArticle

Abstract

Background: Altered inter-regional structural connectivity related to higher cognitive functions has been commonly reported in individuals with autism spectrum disorder (ASD). However, whether these alterations similarly involve cortico-cerebellar motor circuitries remains largely elusive. Methods: Using a cross-modality approach accounting for in-scanner motion levels, we investigated white matter (WM) properties in motor circuits of 55 boys with ASD (aged 8–18 years) and 68 age-matched typically developing boys. Regional WM volumes in the primary motor, supplementary motor, somatosensory, and cerebellar areas were investigated using voxel-based morphometry. Diffusion spectrum imaging tractography was used to estimate WM integrity of the corticospinal, cortico-ponto-cerebellar (including fronto-ponto-cerebellar and parieto-ponto-cerebellar), and dentato-rubro-thalamo-cortical tracts. The reaction time test in the Cambridge Neuropsychological Test Automated Battery was used to assess motor performances. Results: Boys with ASD had shorter movement time, increased WM volumes in the left somatosensory area, but decreased generalized fractional anisotropy value in the left parieto-ponto-cerebellar tract, compared to controls. A positive correlation between movement time and microstructural properties of the left parieto-ponto-cerebellar tract was found in boys with ASD. Conclusions: As the first study to demonstrate altered WM properties in the left somatosensory area, and its descending pathway connecting to the cerebellum in ASD, current results may highlight a potential new target of interventions for motor performance in ASD.

LanguageEnglish
Pages76-83
Number of pages8
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume90
DOIs
Publication statusPublished - Mar 2 2019
Externally publishedYes

Fingerprint

Neuropsychological Tests
Anisotropy
Cerebellum
Cognition
Reaction Time
Autism Spectrum Disorder
White Matter

Keywords

  • Autism spectrum disorder
  • Diffusion spectrum imaging
  • Motor, white matter
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

Cite this

Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder. / Lin, Chia Wei; Lin, Hsiang Yuan; Lo, Yu Chun; Chen, Yu Jen; Hsu, Yung Chin; Chen, Yi Lung; Tseng, Wen Yih Isaac; Gau, Susan Shur Fen.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 90, 02.03.2019, p. 76-83.

Research output: Contribution to journalArticle

Lin, Chia Wei ; Lin, Hsiang Yuan ; Lo, Yu Chun ; Chen, Yu Jen ; Hsu, Yung Chin ; Chen, Yi Lung ; Tseng, Wen Yih Isaac ; Gau, Susan Shur Fen. / Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019 ; Vol. 90. pp. 76-83.
@article{52fcaca687b74dd69c6ded8d107956ee,
title = "Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder",
abstract = "Background: Altered inter-regional structural connectivity related to higher cognitive functions has been commonly reported in individuals with autism spectrum disorder (ASD). However, whether these alterations similarly involve cortico-cerebellar motor circuitries remains largely elusive. Methods: Using a cross-modality approach accounting for in-scanner motion levels, we investigated white matter (WM) properties in motor circuits of 55 boys with ASD (aged 8–18 years) and 68 age-matched typically developing boys. Regional WM volumes in the primary motor, supplementary motor, somatosensory, and cerebellar areas were investigated using voxel-based morphometry. Diffusion spectrum imaging tractography was used to estimate WM integrity of the corticospinal, cortico-ponto-cerebellar (including fronto-ponto-cerebellar and parieto-ponto-cerebellar), and dentato-rubro-thalamo-cortical tracts. The reaction time test in the Cambridge Neuropsychological Test Automated Battery was used to assess motor performances. Results: Boys with ASD had shorter movement time, increased WM volumes in the left somatosensory area, but decreased generalized fractional anisotropy value in the left parieto-ponto-cerebellar tract, compared to controls. A positive correlation between movement time and microstructural properties of the left parieto-ponto-cerebellar tract was found in boys with ASD. Conclusions: As the first study to demonstrate altered WM properties in the left somatosensory area, and its descending pathway connecting to the cerebellum in ASD, current results may highlight a potential new target of interventions for motor performance in ASD.",
keywords = "Autism spectrum disorder, Diffusion spectrum imaging, Motor, white matter, Voxel-based morphometry, Autism spectrum disorder, Diffusion spectrum imaging, Motor, white matter, Voxel-based morphometry",
author = "Lin, {Chia Wei} and Lin, {Hsiang Yuan} and Lo, {Yu Chun} and Chen, {Yu Jen} and Hsu, {Yung Chin} and Chen, {Yi Lung} and Tseng, {Wen Yih Isaac} and Gau, {Susan Shur Fen}",
year = "2019",
month = "3",
day = "2",
doi = "10.1016/j.pnpbp.2018.11.008",
language = "English",
volume = "90",
pages = "76--83",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Alterations in white matter microstructure and regional volume are related to motor functions in boys with autism spectrum disorder

AU - Lin, Chia Wei

AU - Lin, Hsiang Yuan

AU - Lo, Yu Chun

AU - Chen, Yu Jen

AU - Hsu, Yung Chin

AU - Chen, Yi Lung

AU - Tseng, Wen Yih Isaac

AU - Gau, Susan Shur Fen

PY - 2019/3/2

Y1 - 2019/3/2

N2 - Background: Altered inter-regional structural connectivity related to higher cognitive functions has been commonly reported in individuals with autism spectrum disorder (ASD). However, whether these alterations similarly involve cortico-cerebellar motor circuitries remains largely elusive. Methods: Using a cross-modality approach accounting for in-scanner motion levels, we investigated white matter (WM) properties in motor circuits of 55 boys with ASD (aged 8–18 years) and 68 age-matched typically developing boys. Regional WM volumes in the primary motor, supplementary motor, somatosensory, and cerebellar areas were investigated using voxel-based morphometry. Diffusion spectrum imaging tractography was used to estimate WM integrity of the corticospinal, cortico-ponto-cerebellar (including fronto-ponto-cerebellar and parieto-ponto-cerebellar), and dentato-rubro-thalamo-cortical tracts. The reaction time test in the Cambridge Neuropsychological Test Automated Battery was used to assess motor performances. Results: Boys with ASD had shorter movement time, increased WM volumes in the left somatosensory area, but decreased generalized fractional anisotropy value in the left parieto-ponto-cerebellar tract, compared to controls. A positive correlation between movement time and microstructural properties of the left parieto-ponto-cerebellar tract was found in boys with ASD. Conclusions: As the first study to demonstrate altered WM properties in the left somatosensory area, and its descending pathway connecting to the cerebellum in ASD, current results may highlight a potential new target of interventions for motor performance in ASD.

AB - Background: Altered inter-regional structural connectivity related to higher cognitive functions has been commonly reported in individuals with autism spectrum disorder (ASD). However, whether these alterations similarly involve cortico-cerebellar motor circuitries remains largely elusive. Methods: Using a cross-modality approach accounting for in-scanner motion levels, we investigated white matter (WM) properties in motor circuits of 55 boys with ASD (aged 8–18 years) and 68 age-matched typically developing boys. Regional WM volumes in the primary motor, supplementary motor, somatosensory, and cerebellar areas were investigated using voxel-based morphometry. Diffusion spectrum imaging tractography was used to estimate WM integrity of the corticospinal, cortico-ponto-cerebellar (including fronto-ponto-cerebellar and parieto-ponto-cerebellar), and dentato-rubro-thalamo-cortical tracts. The reaction time test in the Cambridge Neuropsychological Test Automated Battery was used to assess motor performances. Results: Boys with ASD had shorter movement time, increased WM volumes in the left somatosensory area, but decreased generalized fractional anisotropy value in the left parieto-ponto-cerebellar tract, compared to controls. A positive correlation between movement time and microstructural properties of the left parieto-ponto-cerebellar tract was found in boys with ASD. Conclusions: As the first study to demonstrate altered WM properties in the left somatosensory area, and its descending pathway connecting to the cerebellum in ASD, current results may highlight a potential new target of interventions for motor performance in ASD.

KW - Autism spectrum disorder

KW - Diffusion spectrum imaging

KW - Motor, white matter

KW - Voxel-based morphometry

KW - Autism spectrum disorder

KW - Diffusion spectrum imaging

KW - Motor, white matter

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=85056806915&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056806915&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2018.11.008

DO - 10.1016/j.pnpbp.2018.11.008

M3 - Article

VL - 90

SP - 76

EP - 83

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

T2 - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -