Abstract

Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of α-tocopherol, the main and most active form of natural vitamin E. α-Tocopherol-associated protein (TAP) was found to be one of the major α-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that α-tocopheryl succinate (α-TOS), a synthetic derivative of α-tocopherol, enhanced the cells' sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.

Original languageEnglish
Pages (from-to)1015-1021
Number of pages7
JournalFood Chemistry
Volume138
Issue number2-3
DOIs
Publication statusPublished - Jun 1 2013

Keywords

  • α-Tocopherol-associated protein
  • Breast cancer
  • Her2/neu receptor
  • Vitamin E

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

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