Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis

Te Sheng Chang, Yu Chih Wu, Shui Yi Tung, Kuo Liang Wei, Yung Yu Hsieh, Hao Chun Huang, Wei Ming Chen, Chien Heng Shen, Chang Hsien Lu, Cheng Shyong Wu, Ying Huang Tsai, Yen Hua Huang

Research output: Contribution to journalArticlepeer-review

60 Citations (Scopus)


Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7%) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95% confidence interval: 0.820-0.868, P

Original languageEnglish
Pages (from-to)836-844
Number of pages9
JournalAmerican Journal of Gastroenterology
Issue number6
Publication statusPublished - Jun 10 2015

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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