Abstract
Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7%) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95% confidence interval: 0.820-0.868, P
| Original language | English |
|---|---|
| Pages (from-to) | 836-844 |
| Number of pages | 9 |
| Journal | American Journal of Gastroenterology |
| Volume | 110 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 10 2015 |
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ASJC Scopus subject areas
- Gastroenterology
- Medicine(all)
Cite this
Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis. / Chang, Te Sheng; Wu, Yu Chih; Tung, Shui Yi; Wei, Kuo Liang; Hsieh, Yung Yu; Huang, Hao Chun; Chen, Wei Ming; Shen, Chien Heng; Lu, Chang Hsien; Wu, Cheng Shyong; Tsai, Ying Huang; Huang, Yen Hua.
In: American Journal of Gastroenterology, Vol. 110, No. 6, 10.06.2015, p. 836-844.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alpha-fetoprotein measurement benefits hepatocellular carcinoma surveillance in patients with cirrhosis
AU - Chang, Te Sheng
AU - Wu, Yu Chih
AU - Tung, Shui Yi
AU - Wei, Kuo Liang
AU - Hsieh, Yung Yu
AU - Huang, Hao Chun
AU - Chen, Wei Ming
AU - Shen, Chien Heng
AU - Lu, Chang Hsien
AU - Wu, Cheng Shyong
AU - Tsai, Ying Huang
AU - Huang, Yen Hua
PY - 2015/6/10
Y1 - 2015/6/10
N2 - Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7%) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95% confidence interval: 0.820-0.868, P
AB - Liver cirrhosis is a major risk factor for hepatocellular carcinoma (HCC), and all liver study societies recommend HCC surveillance in patients with cirrhosis. However, no ideal modality for HCC surveillance has been determined. The aim of this study is to assess the effectiveness of α-fetoprotein (AFP) measurement in HCC surveillance.METHODS:In this retrospective analysis, all patients with cirrhosis, who received HCC surveillance through ultrasound (US) and AFP measurement between January 2002 and July 2010, were followed up until June 2013. The performance effectiveness of surveillance using AFP, US, or both in HCC detection was compared.RESULTS:Overall, 1,597 patients were followed for a median duration of 4.75 (range 1.42-12) years. Over the 8563.25-person-year follow-up period, 363 patients (22.7%) developed HCCs. For HCC detection, the area under the receiver operator characteristic curve of surveillance AFP was 0.844 (95% confidence interval: 0.820-0.868, P
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UR - http://www.scopus.com/inward/citedby.url?scp=84930758143&partnerID=8YFLogxK
U2 - 10.1038/ajg.2015.100
DO - 10.1038/ajg.2015.100
M3 - Article
C2 - 25869392
AN - SCOPUS:84930758143
VL - 110
SP - 836
EP - 844
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
SN - 0002-9270
IS - 6
ER -