Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes: A randomized, crossover, controlled feeding trial

Chiao Ming Chen, Jen Fang Liu, Sing Chung Li, Chen Ling Huang, An Tsz Hsirh, Shuen Fu Weng, Mei Ling Chang, Hung Ta Li, Emily Mohn, C. Y.Oliver Chen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared to NCEP step II diet as control (CON), ~60 g/d almonds (ALM) added to CON would improve glucoregulation and cardiovascular disease (CVD) risk factors in 33 Chinese T2DM patients. Methods: Forty T2DM patients were enrolled and randomly assigned to receive CON or ALM for 12 wks after a 2-wk. run-in period. Blood and urine samples were collected in the beginning and at the end of each dietary intervention phase for the assessment of biomarkers of glucoregulation, lipid profile, inflammation, and oxidative stress. Results: While ALM had a better overall nutritional quality than CON, neither ALM nor CON improved the glycemic status as the primary study outcome and other CVD risk factors, except the circulating nitric oxide being decreased by ALM compared to CON. Among 27 of 33 patients with the baseline HbA1c ≤8, ALM decreased post-interventional fasting serum glucose and HbA1c by 5.9% and 3.0% as compared to that of CON, respectively (P = 0.01 and 0.04). Mean total and LDL-cholesterol concentrations were not changed by both diets. Conclusions: These results suggest almonds incorporated into healthful diets can improve glycemic status in diabetic patients with a better glycemic control. Trial registration: NCT01656850, registered 13 January 2012.

Original languageEnglish
Article number51
JournalNutrition and Metabolism
Volume14
Issue number1
DOIs
Publication statusPublished - Aug 2 2017

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Type 2 Diabetes Mellitus
Diet
Cardiovascular Diseases
Glycemic Index
Tocopherols
Prunus dulcis
Nutritive Value
Oleic Acid
Quality Control
LDL Cholesterol
Fasting
Nitric Oxide
Oxidative Stress
Biomarkers
Outcome Assessment (Health Care)
Urine
Inflammation
Lipids
Glucose
Food

Keywords

  • Almonds
  • Diabetes mellitus
  • HbA1c
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes : A randomized, crossover, controlled feeding trial. / Chen, Chiao Ming; Liu, Jen Fang; Li, Sing Chung; Huang, Chen Ling; Hsirh, An Tsz; Weng, Shuen Fu; Chang, Mei Ling; Li, Hung Ta; Mohn, Emily; Chen, C. Y.Oliver.

In: Nutrition and Metabolism, Vol. 14, No. 1, 51, 02.08.2017.

Research output: Contribution to journalArticle

Chen, Chiao Ming ; Liu, Jen Fang ; Li, Sing Chung ; Huang, Chen Ling ; Hsirh, An Tsz ; Weng, Shuen Fu ; Chang, Mei Ling ; Li, Hung Ta ; Mohn, Emily ; Chen, C. Y.Oliver. / Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes : A randomized, crossover, controlled feeding trial. In: Nutrition and Metabolism. 2017 ; Vol. 14, No. 1.
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T1 - Almonds ameliorate glycemic control in Chinese patients with better controlled type 2 diabetes

T2 - A randomized, crossover, controlled feeding trial

AU - Chen, Chiao Ming

AU - Liu, Jen Fang

AU - Li, Sing Chung

AU - Huang, Chen Ling

AU - Hsirh, An Tsz

AU - Weng, Shuen Fu

AU - Chang, Mei Ling

AU - Li, Hung Ta

AU - Mohn, Emily

AU - Chen, C. Y.Oliver

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N2 - Background: Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared to NCEP step II diet as control (CON), ~60 g/d almonds (ALM) added to CON would improve glucoregulation and cardiovascular disease (CVD) risk factors in 33 Chinese T2DM patients. Methods: Forty T2DM patients were enrolled and randomly assigned to receive CON or ALM for 12 wks after a 2-wk. run-in period. Blood and urine samples were collected in the beginning and at the end of each dietary intervention phase for the assessment of biomarkers of glucoregulation, lipid profile, inflammation, and oxidative stress. Results: While ALM had a better overall nutritional quality than CON, neither ALM nor CON improved the glycemic status as the primary study outcome and other CVD risk factors, except the circulating nitric oxide being decreased by ALM compared to CON. Among 27 of 33 patients with the baseline HbA1c ≤8, ALM decreased post-interventional fasting serum glucose and HbA1c by 5.9% and 3.0% as compared to that of CON, respectively (P = 0.01 and 0.04). Mean total and LDL-cholesterol concentrations were not changed by both diets. Conclusions: These results suggest almonds incorporated into healthful diets can improve glycemic status in diabetic patients with a better glycemic control. Trial registration: NCT01656850, registered 13 January 2012.

AB - Background: Almonds can decrease glycemic index of co-consumed foods and are a rich source for oleic acid and α-tocopherol. The aim of the randomized, crossover, controlled feeding trial was to examine whether as compared to NCEP step II diet as control (CON), ~60 g/d almonds (ALM) added to CON would improve glucoregulation and cardiovascular disease (CVD) risk factors in 33 Chinese T2DM patients. Methods: Forty T2DM patients were enrolled and randomly assigned to receive CON or ALM for 12 wks after a 2-wk. run-in period. Blood and urine samples were collected in the beginning and at the end of each dietary intervention phase for the assessment of biomarkers of glucoregulation, lipid profile, inflammation, and oxidative stress. Results: While ALM had a better overall nutritional quality than CON, neither ALM nor CON improved the glycemic status as the primary study outcome and other CVD risk factors, except the circulating nitric oxide being decreased by ALM compared to CON. Among 27 of 33 patients with the baseline HbA1c ≤8, ALM decreased post-interventional fasting serum glucose and HbA1c by 5.9% and 3.0% as compared to that of CON, respectively (P = 0.01 and 0.04). Mean total and LDL-cholesterol concentrations were not changed by both diets. Conclusions: These results suggest almonds incorporated into healthful diets can improve glycemic status in diabetic patients with a better glycemic control. Trial registration: NCT01656850, registered 13 January 2012.

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KW - HbA1c

KW - Inflammation

KW - Oxidative stress

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