All-cause and cause-specific mortality and long-term exposure to arsenic in drinking water: A prospective cohort study in northeastern Taiwan

B. Y. Hsiao, L. I. Hsu, C. J. Chen, Hung Yi Chiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The association of low-to-moderate arsenic exposure with cause-specific mortality has never been reported in Taiwan. This study aimed to elucidate the dose-response relation of mortality from various causes of death with the arsenic concentration in drinking water and cumulative arsenic exposure. A total of 8,088 residents from northeastern Taiwan were followed from 1991 to 2011. Cox regression analysis was used to determine the hazard ratio of cause-specific mortality associated with two indices of arsenic exposure. A total of 3,106 deaths were ascertained during the follow-up period of 120,768 person-years. The multivariate-adjusted hazard ratio (95% confidence interval) was 1.25 (1.04-1.50), 1.32 (0.96-1.81), 2.41 (1.43-4.05), 4.00 (1.17-13.70), 3.58 (0.92-13.93) and 2.31 (1.43-3.75), respectively, for mortality from all-causes, all cancers, lung cancer, urinary cancer, occlusive stroke, and respiratory disease for arsenic level in drinking water ≥500.0 μg/L compared to

Original languageEnglish
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages580-581
Number of pages2
ISBN (Print)9781138001411
Publication statusPublished - 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

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ASJC Scopus subject areas

  • Chemical Health and Safety

Cite this

Hsiao, B. Y., Hsu, L. I., Chen, C. J., & Chiou, H. Y. (2014). All-cause and cause-specific mortality and long-term exposure to arsenic in drinking water: A prospective cohort study in northeastern Taiwan. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 580-581). CRC Press/Balkema.