Aliphatic phenolic ethers from trichobotrys effusa

Jih Jung Chen, Shih Wei Wang, Hui Yun Hsiao, Ming Shian Lee, Yu Min Ju, Yueh Hsiung Kuo, Zong-Huei Li

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Four novel aliphatic phenolic ethers, namely, trichoethers A-D (1-4), possessing a unique C11-O-C10 skeleton, together with coriloxin, zythiostromic acid A, radicicol, and 3,5-dihydroxytoluene were isolated from the ethyl acetate extracts of the fermented broths of Trichobotrys effusa YMJ1179. The structures of all the compounds were determined based on spectroscopic data analysis. The configurations of 1-4 were established by J values and NOESY and compared with published data. Compounds 1-4 and radicicol exhibited growth-inhibitory activities against the A549 non-small-cell lung cancer cell line with GI50 values of 25.61, 19.32, 16.19, 24.31, and 1.43 μM, respectively, in comparison with 5-fluorouracil (GI50 = 4.55 μM).

Original languageEnglish
Pages (from-to)1097-1101
Number of pages5
JournalJournal of Natural Products
Volume77
Issue number5
DOIs
Publication statusPublished - May 23 2014

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine

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  • Cite this

    Chen, J. J., Wang, S. W., Hsiao, H. Y., Lee, M. S., Ju, Y. M., Kuo, Y. H., & Li, Z-H. (2014). Aliphatic phenolic ethers from trichobotrys effusa. Journal of Natural Products, 77(5), 1097-1101. https://doi.org/10.1021/np400776y