Alcoholic neurobiology: Changes in dependence and recovery

Fulton T. Crews, Tracey Buckley, Peter R. Dodd, Gabriele Ende, Nina Foley, Clive Harper, Jun He, David Innes, El Wui Loh, Adolf Pfefferbaum, Jian Zou, Edith V. Sullivan

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

This article presents the proceedings of a symposium held at the meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) in Mannheim, Germany, in October, 2004. Chronic alcoholism follows a fluctuating course, which provides a naturalistic experiment in vulnerability, resilience, and recovery of human neural systems in response to presence, absence, and history of the neurotoxic effects of alcoholism. Alcohol dependence is a progressive chronic disease that is associated with changes in neuroanatomy, neurophysiology, neural gene expression, psychology, and behavior. Specifically, alcohol dependence is characterized by a neuropsychological profile of mild to moderate impairment in executive functions, visuospatial abilities, and postural stability, together with relative sparing of declarative memory, language skills, and primary motor and perceptual abilities. Recovery from alcoholism is associated with a partial reversal of CNS deficits that occur in alcoholism. The reversal of deficits during recovery from alcoholism indicates that brain structure is capable of repair and restructuring in response to insult in adulthood. Indirect support of this repair model derives from studies of selective neuropsychological processes, structural and functional neuroimaging studies, and preclinical studies on degeneration and regeneration during the development of alcohol dependence and recovery from dependence. Genetics and brain regional specificity contribute to unique changes in neuropsychology and neuroanatomy in alcoholism and recovery. This symposium includes state-of-the-art presentations on changes that occur during active alcoholism as well as those that may occur during recovery-abstinence from alcohol dependence. Included are human neuroimaging and neuropsychological assessments, changes in human brain gene expression, allelic combinations of genes associated with alcohol dependence and preclinical studies investigating mechanisms of alcohol induced neurotoxicity, and neuroprogenetor cell expansion during recovery from alcohol dependence.

Original languageEnglish
Pages (from-to)1504-1513
Number of pages10
JournalAlcoholism: Clinical and Experimental Research
Volume29
Issue number8
DOIs
Publication statusPublished - Aug 1 2005
Externally publishedYes

Fingerprint

Neurobiology
Alcoholism
Alcohols
Recovery
Brain
Gene expression
Functional neuroimaging
Repair
Neurophysiology
Neuroimaging
Neuroanatomy
Aptitude
Genes
Gene Expression
Data storage equipment
Neuropsychology
Functional Neuroimaging
Motor Skills
Executive Function
Germany

Keywords

  • Alcohol Dependence
  • Neuroanatomy
  • Neuroimaging
  • Neuropsychology
  • Recovery

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Crews, F. T., Buckley, T., Dodd, P. R., Ende, G., Foley, N., Harper, C., ... Sullivan, E. V. (2005). Alcoholic neurobiology: Changes in dependence and recovery. Alcoholism: Clinical and Experimental Research, 29(8), 1504-1513. https://doi.org/10.1097/01.alc.0000175013.50644.61

Alcoholic neurobiology : Changes in dependence and recovery. / Crews, Fulton T.; Buckley, Tracey; Dodd, Peter R.; Ende, Gabriele; Foley, Nina; Harper, Clive; He, Jun; Innes, David; Loh, El Wui; Pfefferbaum, Adolf; Zou, Jian; Sullivan, Edith V.

In: Alcoholism: Clinical and Experimental Research, Vol. 29, No. 8, 01.08.2005, p. 1504-1513.

Research output: Contribution to journalArticle

Crews, FT, Buckley, T, Dodd, PR, Ende, G, Foley, N, Harper, C, He, J, Innes, D, Loh, EW, Pfefferbaum, A, Zou, J & Sullivan, EV 2005, 'Alcoholic neurobiology: Changes in dependence and recovery', Alcoholism: Clinical and Experimental Research, vol. 29, no. 8, pp. 1504-1513. https://doi.org/10.1097/01.alc.0000175013.50644.61
Crews, Fulton T. ; Buckley, Tracey ; Dodd, Peter R. ; Ende, Gabriele ; Foley, Nina ; Harper, Clive ; He, Jun ; Innes, David ; Loh, El Wui ; Pfefferbaum, Adolf ; Zou, Jian ; Sullivan, Edith V. / Alcoholic neurobiology : Changes in dependence and recovery. In: Alcoholism: Clinical and Experimental Research. 2005 ; Vol. 29, No. 8. pp. 1504-1513.
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