Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines

Wei J. Chen, E. W. Loh, Yun Pung P. Hsu, Andrew T.A. Cheng

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes may reduce the risk of alcoholism in Oriental populations. In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan. The ethnicity matching used in this study was feasible because there are still few intergroup marriages between these aboriginal groups. On a group level, the rare frequencies of ALDH2*2, the inactive allele of ALDH2 among these aborigines may account partially for their vulnerability to alcohol use disorders. On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.

Original languageEnglish
Pages (from-to)703-709
Number of pages7
JournalBiological Psychiatry
Volume41
Issue number6
DOIs
Publication statusPublished - Mar 15 1997
Externally publishedYes

Fingerprint

Aldehyde Dehydrogenase
Alcohol Dehydrogenase
Alcoholism
Genotype
Alleles
Alcohols
Marriage
Taiwan
Ethnic Groups
Population
Genes

Keywords

  • aborigines
  • alcohol dehydrogenase
  • alcoholism
  • aldehyde dehydrogenase
  • association study
  • genetic

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. / Chen, Wei J.; Loh, E. W.; Hsu, Yun Pung P.; Cheng, Andrew T.A.

In: Biological Psychiatry, Vol. 41, No. 6, 15.03.1997, p. 703-709.

Research output: Contribution to journalArticle

Chen, Wei J. ; Loh, E. W. ; Hsu, Yun Pung P. ; Cheng, Andrew T.A. / Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. In: Biological Psychiatry. 1997 ; Vol. 41, No. 6. pp. 703-709.
@article{b32604fa90f8456092eebbd7f7a69f49,
title = "Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines",
abstract = "Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes may reduce the risk of alcoholism in Oriental populations. In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan. The ethnicity matching used in this study was feasible because there are still few intergroup marriages between these aboriginal groups. On a group level, the rare frequencies of ALDH2*2, the inactive allele of ALDH2 among these aborigines may account partially for their vulnerability to alcohol use disorders. On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.",
keywords = "aborigines, alcohol dehydrogenase, alcoholism, aldehyde dehydrogenase, association study, genetic",
author = "Chen, {Wei J.} and Loh, {E. W.} and Hsu, {Yun Pung P.} and Cheng, {Andrew T.A.}",
year = "1997",
month = "3",
day = "15",
doi = "10.1016/S0006-3223(96)00072-8",
language = "English",
volume = "41",
pages = "703--709",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines

AU - Chen, Wei J.

AU - Loh, E. W.

AU - Hsu, Yun Pung P.

AU - Cheng, Andrew T.A.

PY - 1997/3/15

Y1 - 1997/3/15

N2 - Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes may reduce the risk of alcoholism in Oriental populations. In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan. The ethnicity matching used in this study was feasible because there are still few intergroup marriages between these aboriginal groups. On a group level, the rare frequencies of ALDH2*2, the inactive allele of ALDH2 among these aborigines may account partially for their vulnerability to alcohol use disorders. On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.

AB - Previous population association studies have indicated that certain alleles of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes may reduce the risk of alcoholism in Oriental populations. In this report we determined the genotypes for three genes, ADH2, ADH3, and ALDH2 among subjects with alcohol dependence (n = 159) and ethnically matched normal controls (n = 149) for the four largest aboriginal groups (Atayal, Ami, Bunun, and Paiwan) in Taiwan. The ethnicity matching used in this study was feasible because there are still few intergroup marriages between these aboriginal groups. On a group level, the rare frequencies of ALDH2*2, the inactive allele of ALDH2 among these aborigines may account partially for their vulnerability to alcohol use disorders. On an individual level, however, the genotypes controlling alcohol metabolism did not account for intragroup differences in vulnerability to alcoholism except in the case of ADH2 for the Ami ethnic group.

KW - aborigines

KW - alcohol dehydrogenase

KW - alcoholism

KW - aldehyde dehydrogenase

KW - association study

KW - genetic

UR - http://www.scopus.com/inward/record.url?scp=0030969447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030969447&partnerID=8YFLogxK

U2 - 10.1016/S0006-3223(96)00072-8

DO - 10.1016/S0006-3223(96)00072-8

M3 - Article

VL - 41

SP - 703

EP - 709

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 6

ER -