Albumin batches and B19 parvovirus DNA

J. J. Lefrere, M. Mariotti, I. De la Croix, J. Lerable, M. Thauvin, T. Burnouf, G. Follea

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Abstract

Background: B19 parvovirus (B19) maybe transmitted iatrogenically by blood, and its prevalence in blood donations is estimated at 1 in 3,300 to 1 in 50,000. As a large number of blood donations make up the plasma pools used to produce plasma derivatives, even a virus as rare as B19 in a population of blood donors may result in the frequent contamination of plasma batches. The percentage of albumin batches containing B19 DNA has never been determined. Study Design and Methods: The presence of B19 DNA was investigated by a polymerase chain reaction assay (with a primer pair in the VP1 region) in a total of 12 and 17 batches of 4- and 20-percent albumin, respectively, from two different manufacturers. Results: No B19 DNA was detected in the batches tested. Conclusion: The current fractionation process used to obtain these albumin preparations is seen to allow the efficient degradation and/or elimination of B19.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalTransfusion
Volume35
Issue number5
Publication statusPublished - 1995
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Hematology

Cite this

Lefrere, J. J., Mariotti, M., De la Croix, I., Lerable, J., Thauvin, M., Burnouf, T., & Follea, G. (1995). Albumin batches and B19 parvovirus DNA. Transfusion, 35(5), 389-391.