Ala55Val polymorphism on UCP2 gene predicts greater weight loss in morbidly obese patients undergoing gastric banding

Hsin Hung Chen, Wei Jei Lee, Weu Wang, Ming Te Huang, Yi Chih Lee, Wen Harn Pan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Variability in weight loss has been observed from morbidly obese patients receiving bariatric operations. Genetic effects may play a crucial role in this variability. Methods: 304 morbidly obese patients (BMI ≥39) were recruited, 77 receiving laparoscopic adjustable gastric banding (LAGB) and 227 laparoscopic mini-gastric bypass (LMGB), and 304 matched non-obese controls (BMI ≤24). Initially, all subjects were genotyped for 4 SNPs (single nucleotide polymorphisms) on UCP2 gene in a case-control study. The SNPs significantly associated with morbid obesity (P

Original languageEnglish
Pages (from-to)926-933
Number of pages8
JournalObesity Surgery
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2007

Keywords

  • Gastric banding
  • Gene
  • Mini-gastric bypass
  • Morbid obesity
  • Obesity surgery
  • Predictor
  • UCP2
  • Weight loss

ASJC Scopus subject areas

  • Surgery

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