Abstract
Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.
| Original language | English |
|---|---|
| Pages (from-to) | 1237-1244 |
| Number of pages | 8 |
| Journal | Circulation Journal |
| Volume | 82 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jan 1 2018 |
Fingerprint
Keywords
- Aging
- Atria
- Atrial fibrillation
- Pulmonary veins
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Aging modulates the substrate and triggers remodeling in atrial fibrillation. / Lin, Yung Kuo; Chen, Yi Ann; Lee, Ting I.; Chen, Yao Chang; Chen, Shih Ann; Chen, Yi Jen.
In: Circulation Journal, Vol. 82, No. 5, 01.01.2018, p. 1237-1244.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Aging modulates the substrate and triggers remodeling in atrial fibrillation
AU - Lin, Yung Kuo
AU - Chen, Yi Ann
AU - Lee, Ting I.
AU - Chen, Yao Chang
AU - Chen, Shih Ann
AU - Chen, Yi Jen
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.
AB - Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.
KW - Aging
KW - Atria
KW - Atrial fibrillation
KW - Pulmonary veins
UR - http://www.scopus.com/inward/record.url?scp=85045987474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045987474&partnerID=8YFLogxK
U2 - 10.1253/circj.CJ-17-0242
DO - 10.1253/circj.CJ-17-0242
M3 - Review article
AN - SCOPUS:85045987474
VL - 82
SP - 1237
EP - 1244
JO - Circulation Journal
JF - Circulation Journal
SN - 1346-9843
IS - 5
ER -