Aging modulates the substrate and triggers remodeling in atrial fibrillation

Yung Kuo Lin; Yi Ann Chen; Ting I. Lee; Yao Chang Chen; Shih Ann Chen; Yi Jen Chen

doi:10.1253/circj.CJ-17-0242

Aging modulates the substrate and triggers remodeling in atrial fibrillation

Yung Kuo Lin, Yi Ann Chen, Ting I. Lee, Yao Chang Chen, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journal › Review article › peer-review

17 Citations (Scopus)

Abstract

Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

Original language	English
Pages (from-to)	1237-1244
Number of pages	8
Journal	Circulation Journal
Volume	82
Issue number	5
DOIs	https://doi.org/10.1253/circj.CJ-17-0242
Publication status	Published - Jan 1 2018

Keywords

Aging
Atria
Atrial fibrillation
Pulmonary veins

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1253/circj.CJ-17-0242

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title = "Aging modulates the substrate and triggers remodeling in atrial fibrillation",

abstract = "Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.",

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AU - Chen, Yi Ann

AU - Lee, Ting I.

AU - Chen, Yao Chang

AU - Chen, Shih Ann

AU - Chen, Yi Jen

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N2 - Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

AB - Aging plays a critical role in the genesis of atrial fibrillation (AF) and also increases the risks of cardiac dysfunction and stroke in AF patients. AF is caused by increased AF triggering from abnormalities of the thoracic vein and/or modulated substrate (atrial) with enhancement of AF maintenance. Clinical and laboratory evidence indicates that aging is significant in the creation of atrial electrical and structural remodeling that leads to increased susceptibility to AF occurrence. Aging is commonly associated with cardiovascular comorbidities, oxidative stress, calcium dysregulation, atrial myopathy with apoptosis, and fibrosis, which all contribute to the genesis of AF. This review updates the current understanding of the effects of aging on the pathophysiology of AF.

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KW - Atrial fibrillation

KW - Pulmonary veins

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Aging modulates the substrate and triggers remodeling in atrial fibrillation

Abstract

Keywords

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