Aggressive surgical intervention in end-stage renal disease patients with spinal epidural abscess

Mei Yi Wu, Tsai Sheng Fu, Chih Hsiang Chang, Hsiang Hao Hsu, Ming Yang Chang, Ya Chung Tian, Cheng Chieh Hung, Ji Tseng Fang, Lih Huei Chen, Yung Chang Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Despite advances in imaging, as well as antibiotic and surgical treatment, spinal epidural abscess (SEA) remains a challenging problem in end-stage renal disease (ESRD) patients. This investigation assesses the influence of ESRD on clinical manifestations, complications, and outcomes in patients with SEA. Methods: This study retrospectively reviewed medical records of 41 patients with SEA treated during 2003-2006. The patients comprised two groups: group I (patients with ESRD) and group II (patients without ESRD). Patient characteristics, including age, gender, comorbidities, clinical presentations, laboratory data, locations of epidural abscess, and outcome, were recorded and compared. Results: The final sample comprised 41 patients. The mean age of the subjects was 62 + 12 years. The sample included 12 patients with ESRD and 29 without ESRD. The development of symptoms was similar for both groups. Group I patients displayed higher serum erythrocyte sedimentation rate (ESR) (108 + 26 vs. 81 + 31 mm/h, p = 0.014) and lower serum hematocrit (27.1 + 4.3 vs. 33.7 + 5.1%, p <0.001) than group II patients. Overall survival at 3 months was 88.9% and 93.1% for patients in groups I and II, respectively (p = 0.876). Meanwhile, patients that underwent surgical decompression of epidural abscess received more surgeries than group I patients (1.08 vs. 0.55, p = 0.086), although the difference was not significant. Conclusions: ESRD is a risk factor for repeat surgery in patients with SEA. This investigation suggests that ESRD patients with SEA may require aggressive surgical intervention despite ESRD not affecting their long-term prognosis.

Original languageEnglish
Pages (from-to)582-586
Number of pages5
JournalRenal Failure
Volume33
Issue number6
DOIs
Publication statusPublished - Jul 2011

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Epidural Abscess
Chronic Kidney Failure
Surgical Decompression
Blood Sedimentation

Keywords

  • back pain
  • end-stage renal disease
  • Spinal epidural abscess
  • Staphylococcus aureus
  • surgical decompression

ASJC Scopus subject areas

  • Nephrology
  • Critical Care and Intensive Care Medicine

Cite this

Wu, M. Y., Fu, T. S., Chang, C. H., Hsu, H. H., Chang, M. Y., Tian, Y. C., ... Chen, Y. C. (2011). Aggressive surgical intervention in end-stage renal disease patients with spinal epidural abscess. Renal Failure, 33(6), 582-586. https://doi.org/10.3109/0886022X.2011.585415

Aggressive surgical intervention in end-stage renal disease patients with spinal epidural abscess. / Wu, Mei Yi; Fu, Tsai Sheng; Chang, Chih Hsiang; Hsu, Hsiang Hao; Chang, Ming Yang; Tian, Ya Chung; Hung, Cheng Chieh; Fang, Ji Tseng; Chen, Lih Huei; Chen, Yung Chang.

In: Renal Failure, Vol. 33, No. 6, 07.2011, p. 582-586.

Research output: Contribution to journalArticle

Wu, MY, Fu, TS, Chang, CH, Hsu, HH, Chang, MY, Tian, YC, Hung, CC, Fang, JT, Chen, LH & Chen, YC 2011, 'Aggressive surgical intervention in end-stage renal disease patients with spinal epidural abscess', Renal Failure, vol. 33, no. 6, pp. 582-586. https://doi.org/10.3109/0886022X.2011.585415
Wu, Mei Yi ; Fu, Tsai Sheng ; Chang, Chih Hsiang ; Hsu, Hsiang Hao ; Chang, Ming Yang ; Tian, Ya Chung ; Hung, Cheng Chieh ; Fang, Ji Tseng ; Chen, Lih Huei ; Chen, Yung Chang. / Aggressive surgical intervention in end-stage renal disease patients with spinal epidural abscess. In: Renal Failure. 2011 ; Vol. 33, No. 6. pp. 582-586.
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abstract = "Background: Despite advances in imaging, as well as antibiotic and surgical treatment, spinal epidural abscess (SEA) remains a challenging problem in end-stage renal disease (ESRD) patients. This investigation assesses the influence of ESRD on clinical manifestations, complications, and outcomes in patients with SEA. Methods: This study retrospectively reviewed medical records of 41 patients with SEA treated during 2003-2006. The patients comprised two groups: group I (patients with ESRD) and group II (patients without ESRD). Patient characteristics, including age, gender, comorbidities, clinical presentations, laboratory data, locations of epidural abscess, and outcome, were recorded and compared. Results: The final sample comprised 41 patients. The mean age of the subjects was 62 + 12 years. The sample included 12 patients with ESRD and 29 without ESRD. The development of symptoms was similar for both groups. Group I patients displayed higher serum erythrocyte sedimentation rate (ESR) (108 + 26 vs. 81 + 31 mm/h, p = 0.014) and lower serum hematocrit (27.1 + 4.3 vs. 33.7 + 5.1{\%}, p <0.001) than group II patients. Overall survival at 3 months was 88.9{\%} and 93.1{\%} for patients in groups I and II, respectively (p = 0.876). Meanwhile, patients that underwent surgical decompression of epidural abscess received more surgeries than group I patients (1.08 vs. 0.55, p = 0.086), although the difference was not significant. Conclusions: ESRD is a risk factor for repeat surgery in patients with SEA. This investigation suggests that ESRD patients with SEA may require aggressive surgical intervention despite ESRD not affecting their long-term prognosis.",
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AU - Fu, Tsai Sheng

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AU - Chang, Ming Yang

AU - Tian, Ya Chung

AU - Hung, Cheng Chieh

AU - Fang, Ji Tseng

AU - Chen, Lih Huei

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AB - Background: Despite advances in imaging, as well as antibiotic and surgical treatment, spinal epidural abscess (SEA) remains a challenging problem in end-stage renal disease (ESRD) patients. This investigation assesses the influence of ESRD on clinical manifestations, complications, and outcomes in patients with SEA. Methods: This study retrospectively reviewed medical records of 41 patients with SEA treated during 2003-2006. The patients comprised two groups: group I (patients with ESRD) and group II (patients without ESRD). Patient characteristics, including age, gender, comorbidities, clinical presentations, laboratory data, locations of epidural abscess, and outcome, were recorded and compared. Results: The final sample comprised 41 patients. The mean age of the subjects was 62 + 12 years. The sample included 12 patients with ESRD and 29 without ESRD. The development of symptoms was similar for both groups. Group I patients displayed higher serum erythrocyte sedimentation rate (ESR) (108 + 26 vs. 81 + 31 mm/h, p = 0.014) and lower serum hematocrit (27.1 + 4.3 vs. 33.7 + 5.1%, p <0.001) than group II patients. Overall survival at 3 months was 88.9% and 93.1% for patients in groups I and II, respectively (p = 0.876). Meanwhile, patients that underwent surgical decompression of epidural abscess received more surgeries than group I patients (1.08 vs. 0.55, p = 0.086), although the difference was not significant. Conclusions: ESRD is a risk factor for repeat surgery in patients with SEA. This investigation suggests that ESRD patients with SEA may require aggressive surgical intervention despite ESRD not affecting their long-term prognosis.

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KW - end-stage renal disease

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KW - Staphylococcus aureus

KW - surgical decompression

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