Age-related changes in cerebral hemodynamics and their correlations with cardiac autonomic functions

Chin Hua Fu, Cheryl C H Yang, Terry B J Kuo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives: This study was designed to evaluate the correlations between cerebral hemodynamics and cardiac autonomic functions in aging process using transfer function techniques. Methods: Arterial blood pressure (ABP), middle cerebral artery flow velocity (MCAFV) detected by transcranial Doppler sonography and electrocardiogram were recorded simultaneously in 20 young (27.5 ± 0.9 years) and 20 middle-old-aged (54.3 ± 1.5 years) healthy volunteers. Variability of ABP, MCAFV and heart rate (HR) were diffracted into very low (VLF, 0.016-0.04 Hz), low (LF, 0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) components. Cerebral vasomotor reserve was quantified by specific ABP-MCAFV transfer function measurements. Results: The young group had significantly higher LF transfer phase and HF transfer magnitudes of ABP-MCAFV transfer function; higher HF powers of HR variability; and higher baroreflex sensitivity than those of the middle-old-aged group. LF phase and HF magnitude of ABP-MCAFV transfer function were positively correlated with HF powers of HR variability. Discussion: Although aging process is not obviously associated with changes in the static values of ABP, MCAFV and HR in this study, it is accompanied by significant declines in cerebral vasomotor reserve, cardiac vagal activity and baroreflex sensitivity. Besides, age-related changes in cerebral vasomotor reserve are positively related to those in cardiac vagal activity.

Original languageEnglish
Pages (from-to)871-876
Number of pages6
JournalNeurological Research
Volume28
Issue number8
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

Middle Cerebral Artery
Arterial Pressure
Hemodynamics
Heart Rate
Baroreflex
Doppler Transcranial Ultrasonography
Healthy Volunteers
Electrocardiography

Keywords

  • Baroreflex sensitivity
  • Cerebral vasomotor reserve
  • Frequency-domain analysis
  • Heart rate variability
  • Transcranial Doppler

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Age-related changes in cerebral hemodynamics and their correlations with cardiac autonomic functions. / Fu, Chin Hua; Yang, Cheryl C H; Kuo, Terry B J.

In: Neurological Research, Vol. 28, No. 8, 12.2006, p. 871-876.

Research output: Contribution to journalArticle

@article{e6a6794aef1b4a9099f7fce42f849f35,
title = "Age-related changes in cerebral hemodynamics and their correlations with cardiac autonomic functions",
abstract = "Objectives: This study was designed to evaluate the correlations between cerebral hemodynamics and cardiac autonomic functions in aging process using transfer function techniques. Methods: Arterial blood pressure (ABP), middle cerebral artery flow velocity (MCAFV) detected by transcranial Doppler sonography and electrocardiogram were recorded simultaneously in 20 young (27.5 ± 0.9 years) and 20 middle-old-aged (54.3 ± 1.5 years) healthy volunteers. Variability of ABP, MCAFV and heart rate (HR) were diffracted into very low (VLF, 0.016-0.04 Hz), low (LF, 0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) components. Cerebral vasomotor reserve was quantified by specific ABP-MCAFV transfer function measurements. Results: The young group had significantly higher LF transfer phase and HF transfer magnitudes of ABP-MCAFV transfer function; higher HF powers of HR variability; and higher baroreflex sensitivity than those of the middle-old-aged group. LF phase and HF magnitude of ABP-MCAFV transfer function were positively correlated with HF powers of HR variability. Discussion: Although aging process is not obviously associated with changes in the static values of ABP, MCAFV and HR in this study, it is accompanied by significant declines in cerebral vasomotor reserve, cardiac vagal activity and baroreflex sensitivity. Besides, age-related changes in cerebral vasomotor reserve are positively related to those in cardiac vagal activity.",
keywords = "Baroreflex sensitivity, Cerebral vasomotor reserve, Frequency-domain analysis, Heart rate variability, Transcranial Doppler",
author = "Fu, {Chin Hua} and Yang, {Cheryl C H} and Kuo, {Terry B J}",
year = "2006",
month = "12",
doi = "10.1179/016164106X110463",
language = "English",
volume = "28",
pages = "871--876",
journal = "Neurological Research",
issn = "0161-6412",
publisher = "Maney Publishing",
number = "8",

}

TY - JOUR

T1 - Age-related changes in cerebral hemodynamics and their correlations with cardiac autonomic functions

AU - Fu, Chin Hua

AU - Yang, Cheryl C H

AU - Kuo, Terry B J

PY - 2006/12

Y1 - 2006/12

N2 - Objectives: This study was designed to evaluate the correlations between cerebral hemodynamics and cardiac autonomic functions in aging process using transfer function techniques. Methods: Arterial blood pressure (ABP), middle cerebral artery flow velocity (MCAFV) detected by transcranial Doppler sonography and electrocardiogram were recorded simultaneously in 20 young (27.5 ± 0.9 years) and 20 middle-old-aged (54.3 ± 1.5 years) healthy volunteers. Variability of ABP, MCAFV and heart rate (HR) were diffracted into very low (VLF, 0.016-0.04 Hz), low (LF, 0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) components. Cerebral vasomotor reserve was quantified by specific ABP-MCAFV transfer function measurements. Results: The young group had significantly higher LF transfer phase and HF transfer magnitudes of ABP-MCAFV transfer function; higher HF powers of HR variability; and higher baroreflex sensitivity than those of the middle-old-aged group. LF phase and HF magnitude of ABP-MCAFV transfer function were positively correlated with HF powers of HR variability. Discussion: Although aging process is not obviously associated with changes in the static values of ABP, MCAFV and HR in this study, it is accompanied by significant declines in cerebral vasomotor reserve, cardiac vagal activity and baroreflex sensitivity. Besides, age-related changes in cerebral vasomotor reserve are positively related to those in cardiac vagal activity.

AB - Objectives: This study was designed to evaluate the correlations between cerebral hemodynamics and cardiac autonomic functions in aging process using transfer function techniques. Methods: Arterial blood pressure (ABP), middle cerebral artery flow velocity (MCAFV) detected by transcranial Doppler sonography and electrocardiogram were recorded simultaneously in 20 young (27.5 ± 0.9 years) and 20 middle-old-aged (54.3 ± 1.5 years) healthy volunteers. Variability of ABP, MCAFV and heart rate (HR) were diffracted into very low (VLF, 0.016-0.04 Hz), low (LF, 0.04-0.15 Hz) and high frequency (HF, 0.15-0.4 Hz) components. Cerebral vasomotor reserve was quantified by specific ABP-MCAFV transfer function measurements. Results: The young group had significantly higher LF transfer phase and HF transfer magnitudes of ABP-MCAFV transfer function; higher HF powers of HR variability; and higher baroreflex sensitivity than those of the middle-old-aged group. LF phase and HF magnitude of ABP-MCAFV transfer function were positively correlated with HF powers of HR variability. Discussion: Although aging process is not obviously associated with changes in the static values of ABP, MCAFV and HR in this study, it is accompanied by significant declines in cerebral vasomotor reserve, cardiac vagal activity and baroreflex sensitivity. Besides, age-related changes in cerebral vasomotor reserve are positively related to those in cardiac vagal activity.

KW - Baroreflex sensitivity

KW - Cerebral vasomotor reserve

KW - Frequency-domain analysis

KW - Heart rate variability

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=33845414090&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845414090&partnerID=8YFLogxK

U2 - 10.1179/016164106X110463

DO - 10.1179/016164106X110463

M3 - Article

C2 - 17288748

AN - SCOPUS:33845414090

VL - 28

SP - 871

EP - 876

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 8

ER -