Age may not influence the outcome of patients with severe sepsis in intensive care units

Chin Ming Chen, Kuo-Chen Cheng, Khee Siang Chan, Wen Liang Yu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background This study attempted to determine the association between age and outcome for severe sepsis patients in the intensive care unit (ICU). Methods From May 2004 through April 2005, we conducted a prospective study of patients with severe sepsis in eight ICUs of Chi-Mei Medical Center. Demographic and clinical information, laboratory results, comorbidities, severity scores, mortality, and lengths of stays for both ICU and hospital were analyzed for older (age ≥ 65 years) and younger adult (age <65 years) patients. We analyzed the association between age and outcome and the predictors of hospital mortality. Results Of the 254 patients included, 63.8% were aged ≥65 years. ICU and hospital mortality rates were 50.4% and 55.1%, respectively, for older and younger adult patients. Both groups had similar baseline data, except that the older group had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores, different comorbidities (less active cancer and alcoholism, but higher percentage of cerebral vascular accident) and more neurologic organ failure. Older patients also had higher ICU (54.3% vs. 43.5%, p = 0.097) and hospital mortality (58.0% vs. 50.0%, p = 0.216). Multivariate analyses showed the following predictors of hospital mortality: being female, active cancer, septic shock, acute respiratory distress syndrome, hematological failure, APACHE II scores >25, and inadequate drainage of infection site. Age was not a significant predictor for mortality after adjusting for other factors. Conclusion In this cohort, age was not an important predictor of mortality in ICU patients with severe sepsis. Physicians should consider other risk factors to improve outcomes in these critically ill aged patients.

Original languageEnglish
Pages (from-to)22-26
Number of pages5
JournalInternational Journal of Gerontology
Volume8
Issue number1
DOIs
Publication statusPublished - 2014

Fingerprint

Intensive Care Units
Sepsis
Mortality
Critical Illness
Comorbidity
Drainage
Young Adult
Length of Stay
Demography
Prospective Studies
Physicians
Infection

Keywords

  • aged
  • intensive care unit
  • multiple organ failure
  • outcomes
  • severe sepsis

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Age may not influence the outcome of patients with severe sepsis in intensive care units. / Chen, Chin Ming; Cheng, Kuo-Chen; Chan, Khee Siang; Yu, Wen Liang.

In: International Journal of Gerontology, Vol. 8, No. 1, 2014, p. 22-26.

Research output: Contribution to journalArticle

Chen, Chin Ming ; Cheng, Kuo-Chen ; Chan, Khee Siang ; Yu, Wen Liang. / Age may not influence the outcome of patients with severe sepsis in intensive care units. In: International Journal of Gerontology. 2014 ; Vol. 8, No. 1. pp. 22-26.
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N2 - Background This study attempted to determine the association between age and outcome for severe sepsis patients in the intensive care unit (ICU). Methods From May 2004 through April 2005, we conducted a prospective study of patients with severe sepsis in eight ICUs of Chi-Mei Medical Center. Demographic and clinical information, laboratory results, comorbidities, severity scores, mortality, and lengths of stays for both ICU and hospital were analyzed for older (age ≥ 65 years) and younger adult (age <65 years) patients. We analyzed the association between age and outcome and the predictors of hospital mortality. Results Of the 254 patients included, 63.8% were aged ≥65 years. ICU and hospital mortality rates were 50.4% and 55.1%, respectively, for older and younger adult patients. Both groups had similar baseline data, except that the older group had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores, different comorbidities (less active cancer and alcoholism, but higher percentage of cerebral vascular accident) and more neurologic organ failure. Older patients also had higher ICU (54.3% vs. 43.5%, p = 0.097) and hospital mortality (58.0% vs. 50.0%, p = 0.216). Multivariate analyses showed the following predictors of hospital mortality: being female, active cancer, septic shock, acute respiratory distress syndrome, hematological failure, APACHE II scores >25, and inadequate drainage of infection site. Age was not a significant predictor for mortality after adjusting for other factors. Conclusion In this cohort, age was not an important predictor of mortality in ICU patients with severe sepsis. Physicians should consider other risk factors to improve outcomes in these critically ill aged patients.

AB - Background This study attempted to determine the association between age and outcome for severe sepsis patients in the intensive care unit (ICU). Methods From May 2004 through April 2005, we conducted a prospective study of patients with severe sepsis in eight ICUs of Chi-Mei Medical Center. Demographic and clinical information, laboratory results, comorbidities, severity scores, mortality, and lengths of stays for both ICU and hospital were analyzed for older (age ≥ 65 years) and younger adult (age <65 years) patients. We analyzed the association between age and outcome and the predictors of hospital mortality. Results Of the 254 patients included, 63.8% were aged ≥65 years. ICU and hospital mortality rates were 50.4% and 55.1%, respectively, for older and younger adult patients. Both groups had similar baseline data, except that the older group had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores, different comorbidities (less active cancer and alcoholism, but higher percentage of cerebral vascular accident) and more neurologic organ failure. Older patients also had higher ICU (54.3% vs. 43.5%, p = 0.097) and hospital mortality (58.0% vs. 50.0%, p = 0.216). Multivariate analyses showed the following predictors of hospital mortality: being female, active cancer, septic shock, acute respiratory distress syndrome, hematological failure, APACHE II scores >25, and inadequate drainage of infection site. Age was not a significant predictor for mortality after adjusting for other factors. Conclusion In this cohort, age was not an important predictor of mortality in ICU patients with severe sepsis. Physicians should consider other risk factors to improve outcomes in these critically ill aged patients.

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