Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection

Chuan Mo Lee, Sheng Nan Lu, Chi Sin Changchien, Chau Ting Yeh, Tsung Teng Hsu, Jui-Hsiang Tang, Jing Houng Wang, Deng Yn Lin, Chao Long Chen, Wei Jen Chen

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Abstract

BACKGROUND. There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas. Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection. Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan. Identification of local HCV-endemic areas is important to keep HCV from spreading. This study investigated the etiologic variations of HCC in different geographic areas of Taiwan. METHODS. The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC. They also evaluated the gender ratio and mean age of these patients. RESULTS. The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 613 ± 11.2 years) (P < 0.05). The male-to-female ratio was 4.5:1 for all HCC patients, 7:1 for HBsAg positive HCC patients, and 2.8:1 for anti-HCV positive HCC patient. In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52%, significantly greater than that of Taiwan as a whole (27.6%) (P = 0.07). However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7%, significantly less than that of Taiwan as a whole (P = 0.043). Of a total of 65 Chiayi- based HCC patients, 55.4% were anti-HCV positive and 46.2% were HBsAg positive. In the Chiayi area, results of multiple logistic regression showed that the HCC patients who were are 60 years or older or who were living in the city area both had highly HCV-related disease. CONCLUSIONS. The mean age of patients with HBV-related HCC was significantly lower than that of patients with non-HBV-related HCC. The male-to-female ratio for patients with HBV-related HCC was significantly higher than that of patients with HCV- related HCC. The authors identified an area of Taiwan in which HCV-related HCC was prevalent.

Original languageEnglish
Pages (from-to)1143-1150
Number of pages8
JournalCancer
Volume86
Issue number7
DOIs
Publication statusPublished - Oct 1 1999
Externally publishedYes

Fingerprint

Virus Diseases
Hepatitis B virus
Hepatocellular Carcinoma
Taiwan
Hepacivirus
Hepatitis B Surface Antigens
Hepatitis C Antibodies
Hepatitis B Antibodies
Cercopithecine Herpesvirus 1

Keywords

  • Geographic variation
  • Hepatitis B virus
  • Hepatitis C virus
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection. / Lee, Chuan Mo; Lu, Sheng Nan; Changchien, Chi Sin; Yeh, Chau Ting; Hsu, Tsung Teng; Tang, Jui-Hsiang; Wang, Jing Houng; Lin, Deng Yn; Chen, Chao Long; Chen, Wei Jen.

In: Cancer, Vol. 86, No. 7, 01.10.1999, p. 1143-1150.

Research output: Contribution to journalArticle

Lee, Chuan Mo ; Lu, Sheng Nan ; Changchien, Chi Sin ; Yeh, Chau Ting ; Hsu, Tsung Teng ; Tang, Jui-Hsiang ; Wang, Jing Houng ; Lin, Deng Yn ; Chen, Chao Long ; Chen, Wei Jen. / Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection. In: Cancer. 1999 ; Vol. 86, No. 7. pp. 1143-1150.
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abstract = "BACKGROUND. There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas. Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection. Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan. Identification of local HCV-endemic areas is important to keep HCV from spreading. This study investigated the etiologic variations of HCC in different geographic areas of Taiwan. METHODS. The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC. They also evaluated the gender ratio and mean age of these patients. RESULTS. The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 613 ± 11.2 years) (P < 0.05). The male-to-female ratio was 4.5:1 for all HCC patients, 7:1 for HBsAg positive HCC patients, and 2.8:1 for anti-HCV positive HCC patient. In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52{\%}, significantly greater than that of Taiwan as a whole (27.6{\%}) (P = 0.07). However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7{\%}, significantly less than that of Taiwan as a whole (P = 0.043). Of a total of 65 Chiayi- based HCC patients, 55.4{\%} were anti-HCV positive and 46.2{\%} were HBsAg positive. In the Chiayi area, results of multiple logistic regression showed that the HCC patients who were are 60 years or older or who were living in the city area both had highly HCV-related disease. CONCLUSIONS. The mean age of patients with HBV-related HCC was significantly lower than that of patients with non-HBV-related HCC. The male-to-female ratio for patients with HBV-related HCC was significantly higher than that of patients with HCV- related HCC. The authors identified an area of Taiwan in which HCV-related HCC was prevalent.",
keywords = "Geographic variation, Hepatitis B virus, Hepatitis C virus, Hepatocellular carcinoma",
author = "Lee, {Chuan Mo} and Lu, {Sheng Nan} and Changchien, {Chi Sin} and Yeh, {Chau Ting} and Hsu, {Tsung Teng} and Jui-Hsiang Tang and Wang, {Jing Houng} and Lin, {Deng Yn} and Chen, {Chao Long} and Chen, {Wei Jen}",
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T1 - Age, gender, and local geographic variations of viral etiology of hepatocellular carcinoma in a hyperendemic area for hepatitis B virus infection

AU - Lee, Chuan Mo

AU - Lu, Sheng Nan

AU - Changchien, Chi Sin

AU - Yeh, Chau Ting

AU - Hsu, Tsung Teng

AU - Tang, Jui-Hsiang

AU - Wang, Jing Houng

AU - Lin, Deng Yn

AU - Chen, Chao Long

AU - Chen, Wei Jen

PY - 1999/10/1

Y1 - 1999/10/1

N2 - BACKGROUND. There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas. Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection. Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan. Identification of local HCV-endemic areas is important to keep HCV from spreading. This study investigated the etiologic variations of HCC in different geographic areas of Taiwan. METHODS. The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC. They also evaluated the gender ratio and mean age of these patients. RESULTS. The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 613 ± 11.2 years) (P < 0.05). The male-to-female ratio was 4.5:1 for all HCC patients, 7:1 for HBsAg positive HCC patients, and 2.8:1 for anti-HCV positive HCC patient. In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52%, significantly greater than that of Taiwan as a whole (27.6%) (P = 0.07). However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7%, significantly less than that of Taiwan as a whole (P = 0.043). Of a total of 65 Chiayi- based HCC patients, 55.4% were anti-HCV positive and 46.2% were HBsAg positive. In the Chiayi area, results of multiple logistic regression showed that the HCC patients who were are 60 years or older or who were living in the city area both had highly HCV-related disease. CONCLUSIONS. The mean age of patients with HBV-related HCC was significantly lower than that of patients with non-HBV-related HCC. The male-to-female ratio for patients with HBV-related HCC was significantly higher than that of patients with HCV- related HCC. The authors identified an area of Taiwan in which HCV-related HCC was prevalent.

AB - BACKGROUND. There are etiologic variations of hepatocellular carcinoma (HCC) in different geographic areas. Taiwan is a hyperendemic area for hepatitis B virus (HBV) infection. Hepatitis C virus (HCV) infection also plays an important role in HCC development in Taiwan. Identification of local HCV-endemic areas is important to keep HCV from spreading. This study investigated the etiologic variations of HCC in different geographic areas of Taiwan. METHODS. The authors evaluated the hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV) status of 284 patients (232 male, 52 female) with HCC. They also evaluated the gender ratio and mean age of these patients. RESULTS. The mean age of HBsAg positive patients was significantly lower than the mean age of HBsAg negative patients (52.6 ± 12.3 vs. 613 ± 11.2 years) (P < 0.05). The male-to-female ratio was 4.5:1 for all HCC patients, 7:1 for HBsAg positive HCC patients, and 2.8:1 for anti-HCV positive HCC patient. In Chaiyi County in southern Taiwan, the prevalence of anti-HCV in male HCC patients was 52%, significantly greater than that of Taiwan as a whole (27.6%) (P = 0.07). However, the prevalence of anti-HCV in male HCC patients in Taipei County in northern Taiwan was 8.7%, significantly less than that of Taiwan as a whole (P = 0.043). Of a total of 65 Chiayi- based HCC patients, 55.4% were anti-HCV positive and 46.2% were HBsAg positive. In the Chiayi area, results of multiple logistic regression showed that the HCC patients who were are 60 years or older or who were living in the city area both had highly HCV-related disease. CONCLUSIONS. The mean age of patients with HBV-related HCC was significantly lower than that of patients with non-HBV-related HCC. The male-to-female ratio for patients with HBV-related HCC was significantly higher than that of patients with HCV- related HCC. The authors identified an area of Taiwan in which HCV-related HCC was prevalent.

KW - Geographic variation

KW - Hepatitis B virus

KW - Hepatitis C virus

KW - Hepatocellular carcinoma

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