Abstract
Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age
| Original language | English |
|---|---|
| Pages (from-to) | 464-471 |
| Number of pages | 8 |
| Journal | European Journal of Paediatric Neurology |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1 2015 |
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Keywords
- Age factors
- Child
- Cyclosporine
- Neurotoxicity syndromes
- Seizures
- Status epilepticus
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
Cite this
Age-dependent vulnerability of cyclosporine-associated encephalopathy in children. / Chen, Li Wen; Chen, Jiann Shiuh; Tu, Yi Fang; Wang, Shan Tair; Wang, Lan Wan; Tsai, Yi Shan; Huang, Chao Ching.
In: European Journal of Paediatric Neurology, Vol. 19, No. 4, 01.07.2015, p. 464-471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-dependent vulnerability of cyclosporine-associated encephalopathy in children
AU - Chen, Li Wen
AU - Chen, Jiann Shiuh
AU - Tu, Yi Fang
AU - Wang, Shan Tair
AU - Wang, Lan Wan
AU - Tsai, Yi Shan
AU - Huang, Chao Ching
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age
AB - Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age
KW - Age factors
KW - Child
KW - Cyclosporine
KW - Neurotoxicity syndromes
KW - Seizures
KW - Status epilepticus
UR - http://www.scopus.com/inward/record.url?scp=84931575548&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931575548&partnerID=8YFLogxK
U2 - 10.1016/j.ejpn.2015.02.003
DO - 10.1016/j.ejpn.2015.02.003
M3 - Article
C2 - 25769225
AN - SCOPUS:84931575548
VL - 19
SP - 464
EP - 471
JO - European Journal of Paediatric Neurology
JF - European Journal of Paediatric Neurology
SN - 1090-3798
IS - 4
ER -