Age-dependent vulnerability of cyclosporine-associated encephalopathy in children

Li Wen Chen, Jiann Shiuh Chen, Yi Fang Tu, Shan Tair Wang, Lan Wan Wang, Yi Shan Tsai, Chao Ching Huang

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age

Original languageEnglish
Pages (from-to)464-471
Number of pages8
JournalEuropean Journal of Paediatric Neurology
Issue number4
Publication statusPublished - Jul 1 2015


  • Age factors
  • Child
  • Cyclosporine
  • Neurotoxicity syndromes
  • Seizures
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Age-dependent vulnerability of cyclosporine-associated encephalopathy in children'. Together they form a unique fingerprint.

Cite this