Age-dependent vulnerability of cyclosporine-associated encephalopathy in children

Li Wen Chen; Jiann Shiuh Chen; Yi Fang Tu; Shan Tair Wang; Lan Wan Wang; Yi Shan Tsai; Chao Ching Huang

doi:10.1016/j.ejpn.2015.02.003

Age-dependent vulnerability of cyclosporine-associated encephalopathy in children

Li Wen Chen, Jiann Shiuh Chen, Yi Fang Tu, Shan Tair Wang, Lan Wan Wang, Yi Shan Tsai, Chao Ching Huang

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age

Original language	English
Pages (from-to)	464-471
Number of pages	8
Journal	European Journal of Paediatric Neurology
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/j.ejpn.2015.02.003
Publication status	Published - Jul 1 2015

Keywords

Age factors
Child
Cyclosporine
Neurotoxicity syndromes
Seizures
Status epilepticus

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health

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title = "Age-dependent vulnerability of cyclosporine-associated encephalopathy in children",

abstract = "Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age ",

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T1 - Age-dependent vulnerability of cyclosporine-associated encephalopathy in children

AU - Chen, Li Wen

AU - Chen, Jiann Shiuh

AU - Tu, Yi Fang

AU - Wang, Shan Tair

AU - Wang, Lan Wan

AU - Tsai, Yi Shan

AU - Huang, Chao Ching

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age

AB - Introduction Cyclosporine (CsA) is an immunosuppressant known for its neurotoxicity, which presents with acute encephalopathy and seizures in the most severe form. However, whether there is age-related neurological susceptibility in pediatric population is poorly defined. The study aims to examine the vulnerability of CsA neurotoxicity among different age groups of pediatric patients in terms of occurrence rate, acute presentations, long-term outcomes, and neuroimaging findings. Methods Pediatric patients (age

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KW - Child

KW - Cyclosporine

KW - Neurotoxicity syndromes

KW - Seizures

KW - Status epilepticus

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