Age and rest–activity rhythm as predictors of survival in patients with newly diagnosed lung cancer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Disruption of the rest–activity rhythm in patients with lung cancer can accelerate cancer progression and affect survival. Rest–activity rhythm changes with age. Therefore, we investigated the effects of rest–activity rhythm and age on patients’ survival. A total of 84 patients with lung cancer were recruited, then separated into two groups; younger patients aged under 65 years or elderly patients aged 65 and over. The dichotomy index (I < O) was used to estimate the rest–activity rhythm measured through the actigraphy motion detector. Cox proportional hazards models were adopted to investigate the effects of different variables on the patients’ survival. After adjusting for confounding, the risk of earlier mortality in the younger patients with disrupted I < O were 2.52 (95%CI = 1.09–5.82) times higher than that in the younger patients with robust I < O (p = 0.03), the risk of earlier mortality in the elderly patients with disrupted I < O was 4.08 (95%CI = 1.91–8.68) times higher than that in the elderly patients with robust I < O (p < 0.001). Therefore, age and I < O influence the survival period of patients with lung cancer. Moreover, disrupted I < O has a substantial influence on elderly patients. In conclusion, aging and disrupted rest–activity rhythm negatively and jointly influenced the survival period of the patients with lung cancer and significantly increased their death risk.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalChronobiology International
DOIs
Publication statusPublished - 2018

Fingerprint

Lung Neoplasms
Survival
Actigraphy
Mortality
Proportional Hazards Models

Keywords

  • elderly
  • Lung cancer
  • rest–activity rhythm
  • sleep quality

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

@article{be040fb0e22c4224acfea8652f779f18,
title = "Age and rest–activity rhythm as predictors of survival in patients with newly diagnosed lung cancer",
abstract = "Disruption of the rest–activity rhythm in patients with lung cancer can accelerate cancer progression and affect survival. Rest–activity rhythm changes with age. Therefore, we investigated the effects of rest–activity rhythm and age on patients’ survival. A total of 84 patients with lung cancer were recruited, then separated into two groups; younger patients aged under 65 years or elderly patients aged 65 and over. The dichotomy index (I < O) was used to estimate the rest–activity rhythm measured through the actigraphy motion detector. Cox proportional hazards models were adopted to investigate the effects of different variables on the patients’ survival. After adjusting for confounding, the risk of earlier mortality in the younger patients with disrupted I < O were 2.52 (95{\%}CI = 1.09–5.82) times higher than that in the younger patients with robust I < O (p = 0.03), the risk of earlier mortality in the elderly patients with disrupted I < O was 4.08 (95{\%}CI = 1.91–8.68) times higher than that in the elderly patients with robust I < O (p < 0.001). Therefore, age and I < O influence the survival period of patients with lung cancer. Moreover, disrupted I < O has a substantial influence on elderly patients. In conclusion, aging and disrupted rest–activity rhythm negatively and jointly influenced the survival period of the patients with lung cancer and significantly increased their death risk.",
keywords = "elderly, Lung cancer, rest–activity rhythm, sleep quality",
author = "Chang, {Wen Pei} and Robert Smith and Lin, {Chia Chin}",
year = "2018",
doi = "10.1080/07420528.2017.1391278",
language = "English",
pages = "1--10",
journal = "Annual Review of Chronopharmacology",
issn = "0743-9539",
publisher = "Marcel Dekker Inc.",

}

TY - JOUR

T1 - Age and rest–activity rhythm as predictors of survival in patients with newly diagnosed lung cancer

AU - Chang, Wen Pei

AU - Smith, Robert

AU - Lin, Chia Chin

PY - 2018

Y1 - 2018

N2 - Disruption of the rest–activity rhythm in patients with lung cancer can accelerate cancer progression and affect survival. Rest–activity rhythm changes with age. Therefore, we investigated the effects of rest–activity rhythm and age on patients’ survival. A total of 84 patients with lung cancer were recruited, then separated into two groups; younger patients aged under 65 years or elderly patients aged 65 and over. The dichotomy index (I < O) was used to estimate the rest–activity rhythm measured through the actigraphy motion detector. Cox proportional hazards models were adopted to investigate the effects of different variables on the patients’ survival. After adjusting for confounding, the risk of earlier mortality in the younger patients with disrupted I < O were 2.52 (95%CI = 1.09–5.82) times higher than that in the younger patients with robust I < O (p = 0.03), the risk of earlier mortality in the elderly patients with disrupted I < O was 4.08 (95%CI = 1.91–8.68) times higher than that in the elderly patients with robust I < O (p < 0.001). Therefore, age and I < O influence the survival period of patients with lung cancer. Moreover, disrupted I < O has a substantial influence on elderly patients. In conclusion, aging and disrupted rest–activity rhythm negatively and jointly influenced the survival period of the patients with lung cancer and significantly increased their death risk.

AB - Disruption of the rest–activity rhythm in patients with lung cancer can accelerate cancer progression and affect survival. Rest–activity rhythm changes with age. Therefore, we investigated the effects of rest–activity rhythm and age on patients’ survival. A total of 84 patients with lung cancer were recruited, then separated into two groups; younger patients aged under 65 years or elderly patients aged 65 and over. The dichotomy index (I < O) was used to estimate the rest–activity rhythm measured through the actigraphy motion detector. Cox proportional hazards models were adopted to investigate the effects of different variables on the patients’ survival. After adjusting for confounding, the risk of earlier mortality in the younger patients with disrupted I < O were 2.52 (95%CI = 1.09–5.82) times higher than that in the younger patients with robust I < O (p = 0.03), the risk of earlier mortality in the elderly patients with disrupted I < O was 4.08 (95%CI = 1.91–8.68) times higher than that in the elderly patients with robust I < O (p < 0.001). Therefore, age and I < O influence the survival period of patients with lung cancer. Moreover, disrupted I < O has a substantial influence on elderly patients. In conclusion, aging and disrupted rest–activity rhythm negatively and jointly influenced the survival period of the patients with lung cancer and significantly increased their death risk.

KW - elderly

KW - Lung cancer

KW - rest–activity rhythm

KW - sleep quality

UR - http://www.scopus.com/inward/record.url?scp=85034212619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034212619&partnerID=8YFLogxK

U2 - 10.1080/07420528.2017.1391278

DO - 10.1080/07420528.2017.1391278

M3 - Article

AN - SCOPUS:85034212619

SP - 1

EP - 10

JO - Annual Review of Chronopharmacology

JF - Annual Review of Chronopharmacology

SN - 0743-9539

ER -